An antispasmodic affects the intestines and, to a lesser extent, other gastrointestinal organs. "Trimedat" helps with dyspepsia, spastic colitis, flatulence. A feature of the treatment of gastrointestinal diseases is the need to regulate motility in order to get rid of spasm (colic), pain, and diarrhea.

Composition of the tablets

Different manufacturers produce the drug only in tablet form. The content of the active ingredient varies. The tablets contain 100, 200 or 300 mg of trimebutin maleate. The remaining components, including lactose, are auxiliary.

  • The Trimedat tablets, 200 mg and the Trimedat forte are prescribed only for adults. For the treatment of preschoolers and adolescents up to 12 years old, they use the drug with the lowest dosage.
  • Children's "Trimedat", 100 mg contains the same active and auxiliary ingredients. A child under 12 years old is not given a whole pill, but ¼ or ½ depending on age.

Pharmacological action, pharmacodynamics and pharmacokinetics

The tool regulates the contraction of the muscular walls of the digestive tract. Wavy movements, called "peristalsis", are necessary to move the contents from the esophagus to the anus. In addition, reductions help to better wet the food with juices that contain enzymes to break down nutrients.

Normalization of intestinal motility is achieved due to the dual function of trimebutin.The medicine acts as an antispasmodic for hyperactivity of smooth muscle cells, and stimulates them with insufficient activity.

"Trimedat" is taken for gastrointestinal disorders that are accompanied by pain. As the researchers suggest, the antispasmodic has a local anesthetic effect. The active ingredient interacts with opiate receptors responsible for pain. They are widespread in the digestive tract and other organs.

Trimebutin 60 minutes after absorption in the small intestine can reach a high plasma concentration. Drug metabolism occurs in the liver. The final transformation products are excreted by the urinary organs in 24 hours.

Why is Trimedat prescribed?

An antispasmodic helps with symptoms caused by impaired gastrointestinal tract and biliary tract. The drug is used for disorders of intestinal motility. Usually, "Trimedat" is prescribed for abdominal discomfort and pain, which are accompanied by digestive disorders.

Gastroenterologists recommend taking "Trimedat" with the following indications:

  • dyspepsia in children, painful digestion, heaviness in the abdomen, early satiety;
  • functional dyspepsia, abdominal pain, vomiting, poor digestion;
  • irritable bowel syndrome, colic, flatulence, constipation or diarrhea;
  • the need to study the gastrointestinal tract by methods of radiology, endoscopy, etc .;
  • gastroesophageal reflux.

"Trimedat" is prescribed as a symptomatic agent for the treatment of postoperative paralytic ileus. This condition is usually associated with abdominal surgery. Postoperative bowel obstruction is manifested in the fact that peristalsis stops.

Instructions for use and dosage for adults and children

The dosage regimen and duration of use are affected by the indications and age of the patients. Therefore, single and daily doses vary. Adults and adolescents over 12 years of age can take from 300 to 600 mg of trimebutin per day, which corresponds to 1-2 tablets of 100 or 200 mg three times a day (600 mg is the maximum dose).

It is recommended to drink tablets with a sufficient amount of liquid for half an hour before each main meal. If it does not work, then you can take the medicine 20 minutes after eating.

After the main course of therapy for irritable bowel syndrome, treatment with Trimedat is continued for another 2 to 3 months to prevent relapse.

Manufacturers in the instructions for use do not recommend breaking or crushing tablets in any other way. However, "children's" single doses are less than the content of trimebutin in one pill.

  • Babies 3-5 years old should be given 25 mg. If you divide the tablets for children at intersecting risks, then each part will contain 25 mg.
  • At the age of 5 to 12 years, 50 mg are prescribed three times a day. When dividing 200 mg pills, 4 parts of 50 mg are obtained.

During pregnancy and lactation

Trimebutin almost does not pass through the placental barrier. In experimental trials, no negative effect was found - direct or indirect - on the development of the fetus, the child. In clinical trials, the safety of Trimedat during pregnancy was not tested. There is little information about whether the concentration of the drug in breast milk reaches dangerous values.

Doctors, based on the current situation, with caution prescribe "Trimedat" in the second and third trimesters of pregnancy. During breastfeeding - only on condition that the benefits of treatment for the mother are more significant, compared with the potential danger to the infant.

Drug interaction

The annotation does not contain information on the mutual influence of Trimedat and other drugs, or a decrease or enhancement of the therapeutic effect. The doctor cancels or changes one medicine to another, depending on the specific situation. Simultaneous use can lead to a negative result.

Often the effect of some drugs in the presence of others increases.The release of combined products is based on this property. It can be assumed that other antispasmodics enhance the effect of trimebutin.

Alcohol Trimedate Compatibility

In addition to other medicines, alcohol and nicotine can change the effects of drugs. They enhance the secretion of digestive juices, in addition, are toxic to varying degrees. “Trimedat” normalizes gastrointestinal motility, alcohol enhances it, therefore, when used together, the therapeutic effect may decrease.

Such findings are not based on special studies. The manufacturers of "Trimedat" did not study the interaction of the drug with ethyl alcohol. Common sense suggests that alcoholism and unhealthy habits complicate the treatment of diseases.

Contraindications, side effects and overdose

"Trimedat" in any dosage cannot be taken with hypersensitivity to the active and / or auxiliary components. Other contraindications are: I trimester of pregnancy, mechanical intestinal obstruction, toxic megacolon (enlargement of the colon). "Trimedat" is not prescribed for children under 3 years old, "forte" - up to 12 years.

Side effects that may develop in response to the use of the drug:

  • pain in the upper abdomen;
  • intense thirst;
  • nausea;
  • diarrhea;
  • constipation;
  • rash.

Negative manifestations of the nervous and cardiovascular systems occur very rarely. Trimebutin is well tolerated by most patients. If an overdose occurs, it is recommended to rinse the stomach. There is no antidote.

Cheap analogues of the drug

The medicine is produced in South Korea and the Russian Federation.

The cost of Trimedat produced by the Russian company Valenta Pharmaceuticals:

  • for children - 338 rubles. (10 pieces.);
  • with a dosage of 200 mg - 466 rubles. (30 pcs.);
  • "Forte" with a prolonged effect - 649 rubles. (20 pcs.).

Another drug contains trimebutin as the only active ingredient. The full structural analogue of Trimedat is Neobutin.

This tool is also produced in Russia.

The price of pills:

  • 100 mg - 195 rub. (10 pieces.);
  • 200 mg - 387 rub. (30 pcs.);
  • "Retard", 300 mg - 445 rubles. (20 pcs.).

A wider range of applications, compared with trimebutine, in other antispasmodics - drotaverine, mebeverin, papaverine. Trade names: “No-shpa”, “Spazmonet”, “Duspatalin”, “Sparex”. Means are intended to eliminate intestinal and biliary colic, treatment of IBS. Cheap analogues of "Trimedat" can be selected among the drugs of this group.

Prices (in rubles): “Spazmonet” - 80, “No-spa” - 200, “Sparex” - 400, “Duspatalin” - 520.

  • Smecta is prescribed for the same indications as Trimedat. The powder is dissolved in water and taken with heartburn, flatulence, diarrhea. The price of packaging is 150 rubles.
  • The mechanism of action of Iberogast drops is not well understood. The preparation contains extracts of 9 plants, each of which is a complex of various bioactive substances. "Iberogast" regulates the motility of the gastrointestinal tract (as "Trimedat"), has anti-inflammatory, antispasmodic, antimicrobial effects (against Helicobacter pylori). The price of the bottle is 770 rubles.
  • Pepsan-R is used for the same indications as Trimedat. Capsules and gel for oral administration contain dimethicone and guizulen, which reduce the production of acid in the stomach, the formation of gas in the intestines. The drug best helps with heartburn and flatulence. Price - 350 rubles. (30 capsules).
  • "Colofort" (homeopathic medicine) is a remedy for the treatment of functional disorders, irritable bowel syndrome, and unspecified gastrointestinal diseases. The price of packaging is 360 rubles. (100 tablets).
  • "Ganaton", "Itomed", "Itopra" - tablets used for functional dyspepsia, in particular - with rapid saturation, severity and pain in the abdomen, heartburn, flatulence. The preparations contain itoprid, contraindicated until 16 years of age. The price of tablets is 385 rubles. (40 pcs.).

Other antispasmodics are group analogues or substitutes for Trimedat.There are drugs that act in a similar way, but having differences in indications and contraindications.

Antispasmodic "Trimedat" acts on muscle fibers in the walls of the digestive tract. The drug relieves symptoms in violation of the motor function of the digestive tract, mainly the intestines.

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