Hormonal imbalance does not always require special therapy. Violation in an unreleased stage can be eliminated with the help of substitution treatment based on synthetic hormone substitutes. Duphaston tablets are indicated for a lack of progesterone, but although the drug has a minimum of side effects and contraindications, it is necessary to find out all the features of its administration.
Material Content:
- 1 Composition and release forms
- 2 Pharmacological action and pharmacokinetics
- 3 Indications for the use of a hormonal drug
- 4 Instructions for taking Duphaston tablets
- 5 Special instructions when planning a child
- 6 During pregnancy and lactation
- 7 Contraindications, side effects, overdose
- 8 Duphaston's analogs
Composition and release forms
Duphaston is available only in the form of tablets, since it can not be used in any other form. These are small round tablets with an engraving, color - white. Each contains 10 mg of didrogesterone - the most active component in the composition. Among other substances, Duphaston includes starch, magnesium stearate, lactose, silicon dioxide, methylhydroxypropylcellulose and the opadray dye, which provides the drug in white.
Pharmacological action and pharmacokinetics
Dydrogesterone is a synthetic analogue of gesterone, a natural hormone responsible for the normal course of the menstrual cycle, conception and development of the fetus. Despite the similar composition, Dufaston's active substance is not a derivative of testosterone, but only an artificially created structural analogue. This saves him from the list of negative effects inherent to progesterone: anabolic (tissue buildup in the body), sedative, anxiolytic (tranquilizer effect), antipsychotic and some other types.
The principle of the work of dydrogesterone is based on a selective effect on the endometrium, which reduces the risk of hyperplasia of the uterine mucosa (pathological proliferation of tissues) and carcinogenesis (the initial stage of tumor formation). Such conditions develop in the presence of excess estrogen in the blood. Dydrogesterone controls the activity of the female hormone, which prevents its trophic effect.
Another advantage of the drug is the absence of a detrimental effect on the blood coagulation process, which greatly depends on the amount of estrogen, does not affect the processing of substances in the liver.
Dydrogesterone does not violate the menstrual cycle, does not affect ovulation, and therefore is not an oral contraceptive, unlike many hormonal drugs.
It is rapidly absorbed in the stomach and intestines, the maximum amount in the blood is detected within 2 hours after the start of administration. It binds to proteins in plasma by 97%.
The bioavailability indicator is 28%.
Recycled completely. When excreted from the body, no traces of unearned substance were found. Inactive metabolites are present in the urine (about 60–70%), which indicates their excretion by the kidneys.
Indications for the use of a hormonal drug
It is recommended to take Duphaston in the presence of the first signs of progesterone deficiency and the diseases resulting from it:
- endometriosis (growth of endometrial cells);
- miscarriage due to a lack of hesterone;
- PMS (premenstrual syndrome);
- infertility with lutein deficiency;
- irregular menstrual cycle, its disorders in the form of dysmenorrhea (severe pain in the lower abdomen during the first days of the cycle), amenorrhea (absence of menstruation for a long period);
- dysfunctional (abnormal) uterine bleeding.
Instructions for taking Duphaston tablets
Dosage and intervals between doses directly depend on the type and severity of the gynecological disease.
How to take Duphaston tablets is indicated in the table below.
| Type of disease | Daily Dose (mg) | The number of receptions per day | Consumption time |
|---|---|---|---|
| Infertility | 10 | 1 | 14-25 day cycle |
| Habitual miscarriage | 20 | 2 | Until the 20th week of pregnancy |
| ICP | 20 | 2 | 11-25 day of the menstrual cycle |
| Endometriosis | 20-30 (depending on the neglect of the disease) | 2-3 | 5–25 days of the cycle |
| Threatening miscarriage | 40 mg once, then 10 mg at intervals of 8 hours until the disappearance of the main signs of a miscarriage | ||
| Dysmenorrhea | 20 | 2 | 5–25 days |
| Amenorrhea | 20 | 2 | 11-25 days |
| Prevention of uterine bleeding | 20 | 2 | 11–25 days of the cycle |
| Uterine Hemorrhage | 20 | 2 | Within five to seven days |
| Irregular cycle | 20 | 2 | 11–25 days of the cycle |
Uterine Hemorrhage
If the drug does not bring the necessary results, then it is allowed to increase a single dose to 20 mg (daily, respectively, - 40 mg).
The tablets are taken orally with a little water. You can not attach to meals.
Special instructions when planning a child
Several unsuccessful pregnancies that end in miscarriages, or simply a lack of progesterone, the hormone responsible for the normal development of the fetus, make women look for the most effective drugs to increase the chances of having a baby. However, if the matter is in the above reasons, the reception of Dufaston will help solve the problem.
With prolonged inability to become pregnant, it is taken exclusively after ovulation - from 11 to 25 days of the cycle. The period of therapy before the onset of the effect can be up to 6 months.
When a pregnancy test has shown a positive result, do not stop taking it, up to 20 weeks.
Due to a sharp interruption, a decrease in progesterone levels can occur, which will provoke a spontaneous miscarriage.
And it should also be systematically examined by a gynecologist, monitor the amount of hormones in the blood and, if necessary, adjust the dose.
It is also important to lead a healthy lifestyle, as many endocrine disorders arise precisely because of malnutrition or the presence of bad habits.
During pregnancy and lactation
The drug is often used to ensure the normal conception and development of the fetus, therefore Duphaston is recommended for use during pregnancy (only if indicated). Do not self-medicate during such a period if such measures are not indicated by a doctor. Otherwise, such actions can harm not only the mother, but also the child.
Dydrogesterone has a tendency to pass into breast milk, so during lactation it is necessary to choose the appropriate analogue or refuse breastfeeding.
The lack of contraceptive properties and a direct effect on ovulation suggests that Dufaston does not affect the reproductive function of women.
Contraindications, side effects, overdose
The successful formula of didrogesterone minimizes contraindications and the negative effects of the drug. You can not prescribe a remedy in the presence of allergic reactions to the main active substance. Due to the lactose present in the composition, patients who have a rare hereditary intolerance to this carbohydrate should be avoided.
Side effects are also few in number and pose virtually no danger to life, with rare exceptions.
Among those marked:
- minor skin rashes, redness, accompanied by itching, swelling on the face or its individual areas (for example, eyelids), extremely rarely - Quincke's edema;
- the appearance of aching headaches, migraine attacks, if there is a predisposition to them;
- infrequently - mild liver dysfunction, jaundice, pain in the abdomen;
- extremely rare anemia develops.
Sometimes irregular uterine bleeding also appears, which is not considered a reason for refusing the drug. A side effect is quickly eliminated by increasing the amount of substance taken.
An overdose of Duphaston has not yet been reported, which makes it difficult to compile a clinical picture of this phenomenon. High probability of occurrence of dyspeptic disorders. It is recommended to thoroughly rinse the stomach if a dose in excess of the specified dose was accidentally taken. Specific treatment is not provided, only symptomatic therapy.
Duphaston's analogs
To date, Duphaston is produced only by the Dutch pharmacological firm Solvay S.A., therefore, it is extremely difficult to find structural analogues of the drug. In medical practice, drugs containing gestagens are considered to be such - hormones that are produced in the body with the help of the corpus luteum, but due to their lack requiring additional administration by artificial means. The therapeutic effect is somewhat different, but the indications are largely the same.
Progesterone is one of the most popular drugs for endometriosis, amenorrhea, infertility, uterine bleeding, and frequent miscarriages. May serve as an oral contraceptive. The hormone is administered intramuscularly.
Prajisan - Indian hormone-based progesterone tablets. They are prescribed for infertility, lack of ovulation, mastopathy, for the prevention of endometriosis. The tool can be used during pregnancy, but is contraindicated in cases of suspected malignant tumors and bleeding.
Utrozhestan is a Belgian hormonal drug that, according to reviews, is well perceived by the body. The medicine is indicated for mastopathy, uterine bleeding, delays in fetal development, infertility. It is forbidden to women with liver dysfunction, a tendency to thrombosis, as well as in the presence of cancer.
Vizan is a German drug that is used exclusively for the treatment of endometriosis. The main substance is dienogest, which has progesterone activity and reduces the degree of trophic effects of estradiol, which blocks the further growth of the endometrium.The tool has a significant number of side effects, but at the moment it is one of the most effective for the treatment of endometriosis.
Iprozhin is a progesterone drug made in Italy. The composition is designed to normalize the menstrual cycle, helps to relax the muscles of the uterus and the proper development of the endometrium. It is indicated with the threat of spontaneous miscarriage, mastopathy, with menopause. It has an increased load on the liver, and therefore is prohibited in the presence of diseases of this organ. It is used with caution during pregnancy and lactation.
Do not independently look for a cheaper or more expensive substitute. Only a doctor can pick up another medication. Inappropriate use of drugs can lead to serious health problems.
Duphaston is a drug based on dydrogesterone, which is used as a hormone replacement therapy. Despite the fact that it has a minimal number of side effects and contraindications, it cannot be used for self-medication, and before starting therapy as directed, it is important to familiarize yourself with the instructions for use and other details regarding the administration.
