De-Nol tablets are anti-ulcer drugs. They proved effective against Helicobacter bacteria, have a protective effect on the mucous membrane of the digestive tract from irritation of hydrochloric acid.
Material Content:
The composition of the drug
The composition of De-Nol includes an active component - bismuth tripotassium dicitrate, dosage of 120 mg.
In addition to the active substance, tablets consist of the following auxiliary ingredients:
- corn starch;
- magnesium stearate;
- potassium polyacryl;
- macrogol.
De Nol is a Dutch company drug manufactured exclusively in tablet form. Packed in blisters for 8 pcs.
Pharmacological properties and pharmacokinetics
De-Nol is represented by a medicament used to treat duodenal ulcer and stomach. The active substance effectively fights the bacterium helicobacter.
Instructions for use indicate the following pharmacological properties of the drug:
- relieves the inflammatory process of the gastrointestinal mucosa;
- It has an astringent effect, covering the mucous membrane with a special layer, protecting the stomach from the harmful effects of hydrochloric acid;
- promotes the healing of ulcers formed, accelerates the process of scarring;
- increases the number of prostaglandins;
- promotes the formation of mucus;
- thanks to the antimicrobial action, pathogens in the gastric cavity are eliminated;
- has a beneficial effect on the liver;
- allows you to relieve irritable stomach syndrome;
- It has an analgesic effect due to penetration into the depths of tissues.
After the treatment course, De-Nol has a positive effect on the general condition of the patient.
What helps De Nol
More detailed information, from which De-Nol helps, will be given by the attending physician. This medication has a large number of advantages, due to which it is widely used for the treatment of many diseases of the digestive system.
The following indications for the use of De-Nol are known:
- heartburn;
- loose stools;
- ulcer of any stage;
- gastritis;
- gastroduodenitis.
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It is recommended to take De-Nol tablets for discomfort, which has no connection with the gastrointestinal tract pathologies, and is manifested by vomiting, nausea, bloating, belching. The medicine is able to stop the pain in case of stomach diseases.
To note, there are known cases of the appointment of De-Nol against the background of prolonged use of oral contraceptives, non-steroidal inflammatory drugs, aspirin and ibuprofen-containing drugs.
Instructions for use for adults and children
In the presence of unpleasant symptoms from the gastrointestinal tract, you must consult a doctor. Based on the diagnosis, he will give recommendations on the exact dosage and duration of the therapeutic course.
The calculation of the dose is made from the condition of the patient, his age, the presence of concomitant diseases, the type and severity of the disease. The following dosage is usually prescribed:
- upon reaching 12 years, it is recommended to drink four times a day for 1 tablet;
- for children 8-12 years old, it is recommended to drink 1 tablet. twice a day;
- for children under 8 years of age, an individual dosage calculation is performed. For 1 kg of body weight, 8 mg of medication is necessary.
Important! Tablets are not prescribed for children under 4 years of age.
The recommended dose is usually divided into 2, 4 doses. You can drink three times a day for 1 tablet. 30 minutes before meals and 1 tablet. for the night. It is allowed to drink 2 tablets. 30 minutes before meals in the morning and evening.
The tablets are coated with an enteric film, so they can not be crushed, chewed. The medicine is completely swallowed and washed down with a sufficient amount of clean water. It is forbidden for half an hour before drinking De Nol and after drinking milk, since the medicine helps to form a protective film. This process requires gastric juice.
The usual therapeutic course lasts from one to two months. Next is an 8-week break in the use of De-Nol, during which it is forbidden to use any medication with bismuth.
Therapy of a gastrointestinal ulcer caused by the Helicobacter bacterium is performed in the following combined ways:
- a combination of De-Nol, Clathrimycin, Amoxicycline, 1 tab. twice a day;
- a combination of De-Nol, Metronidazole, Tetracycline, Omeprazole 1 table. thrice.
Combination therapy lasts for 1-2 weeks, depending on the severity of the disease. In order to prevent further damage to the mucosa, prolongation of De-Nol therapy for another 1.5 months is prescribed.
Important! It is forbidden to drink De-Nol juice, milk, carbonated drinks.
During pregnancy and lactation
Medicine does not have reliable information on how safe De-Nol therapy is for pregnant and lactating women. Therefore, if during pregnancy the expectant mother has stomach problems, it is recommended to consult a doctor to select a safe treatment. The active substance that is part of the drug passes into breast milk, so during the period of treatment with tablets of the child should be transferred to artificial feeding.
Drug interaction
Patients usually tolerate De Nol well. However, there are some groups of drugs that are undesirable to be taken at the same time with this medication.
It is worth abandoning the combination:
- with tetracyclines, since the absorption of the antibacterial drug decreases;
- with medicines containing bismuth, since the concentration of the active component in the circulatory system increases;
- with antacids, since the effectiveness of De-Nol is significantly reduced.
It is not recommended to combine the use of tablets with milk, fruit, juice, since in this case the effectiveness of the drug significantly decreases.
Contraindications, side effects and overdose
Typically, patients tolerate De-Nol therapy well, but tablets have a number of contraindications.
Do not drink them in the following cases:
- with intolerance to bismuth-containing drugs;
- with hypersensitivity to excipients;
- in the presence of renal failure;
- during pregnancy;
- during lactation;
- in children under 4 years old.
Side effects are known.
Usually patients complain of the following negative reactions from the body:
- nausea
- bloating;
- metallic taste in the mouth;
- vomiting
- general weakness;
- skin rashes;
- urticaria;
- anaphylactic shock;
- itching
During treatment with De-Nol, the feces often acquire a dark color, the color of the tongue changes. If adverse reactions occur, you should visit a doctor to assess the patient's condition and decide on the further advisability of taking the medication.
If the patient is prescribed long-term administration of the drug in large doses, then side effects may develop from the body, manifested:
- gingivitis;
- nephropathy;
- encephalopathy;
- arthralgia;
- colitis.
This is due to the possibility of accumulation of the active substance in the central nervous system, on the basis of which the self-administration of De-Nol is prohibited. It is not recommended to increase the treatment course for more than 2 months. Unwanted reactions from the body do not require treatment. They pass after stopping the pill.
Cases of overdose are expressed in general intoxication, malfunctioning of the kidneys. In this case, gastric lavage is necessary to prevent the absorption of the active ingredient. It is recommended to take a salt-based laxative. In extreme cases, hemodialysis is required.
Analogues of the drug
De Nol belongs to the drugs of a high price category. In this connection, patients are often interested in the analogue of De-nol.
Known substitutes for the original include the following medications:
- Vicair, which consists of bismuth, sodium, magnesium, buckthorn bark. The active ingredients allow you to remove high acidity, have a mild laxative effect.
- Novobismol. It is based on bismuth. During treatment, a film of protective action against irritation of the mucosa by gastric juice is formed.
- Escape. The drug is on bismuth. Its action is based on the formation of a protective film that quickly regenerates ulcerative processes.
- Ulkavis. The medication is also based on a bismuth derivative. It speeds up the healing process of erosion of the digestive tract.
Replacement of the original with analogs is necessary only after consultation with a doctor in order to avoid negative effects of a drug on the body.
De-Nol - tablets for stomach ulcers, eliminating the negative effect of hydrochloric acid on the gastrointestinal mucosa.
