Today, Azithromycin tablets are considered the most popular drug with an antibacterial effect. They are prescribed as a complex therapy for many disorders of a bacterial nature, in particular, for infectious diseases of the respiratory system. The medication is safe for both adults and children.

Composition (active substance) of tablets

The antibiotic Azithromycin can be purchased in the following forms:

  • tablets - 125, 250 and 500 mg each;
  • capsules - 250 and 500 mg each.

Azithromycin (in the form of a dihydrate) acts as the main active substance. And also there are a number of additional compounds: starch, calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate. The coating consists of titanium dioxide, macrogol, talc. One carton contains 3 tablets.

Pharmacological properties and indications for use

A feature of this drug is increased activity against most gram-positive and gram-negative microorganisms. Pharmacological properties are due to the ability of the main substance to accumulate in the affected area and for a long time to act on pathogenic microbes. The detrimental effect on the vital activity of bacteria and the suspension of their reproduction occurs due to the bacteriostatic effect of the drug.However, in sufficiently large dosages, the medication is able to act bactericidal.

Antibiotic agents from the macrolide group have a mild and gentle effect on the human body, as well as less toxicity. The cumulative property and a long withdrawal period of the drug helps to prevent relapse and reduce the therapeutic course. In addition, Azithromycin is able to infect intracellular harmful organisms (mycoplasmas, chlamydia).

The purpose of this medication is justified in such cases:

  1. The defeat of the ENT organs - sinuses, nasopharynx and throat (sinusitis, rhinitis, scarlet fever, sinusitis, tonsillitis and otitis media).
  2. Infections of the lower respiratory tract - bronchi and trachea (pneumonia, bronchitis and chronic inflammation).
  3. Infections of the genitourinary system (cystitis, prostatitis, chlamydia).

In addition, in some cases, the appointment is the early stage of Lyme disease, as well as some skin infections that affect soft tissues. As an additional tool, it is recommended to eliminate the pathogenic bacteria that cause gastritis and ulcer. Azithromycin is prescribed for adults, children and elderly patients.

Which group of antibiotics belongs

Azithromycin is a derivative antibiotic of the macrolide group - a subclass of azalides. The bacteriostatic property is ensured by the violation of the protein metabolism of hostile cells.

Instructions for use with Azithromycin tablets

Azithromycin is recommended to be taken before meals or 2 hours after. The tablets do not need to be chewed, and you need to drink them with a glass of clean water.

The dosage of the drug is calculated depending on the diagnosis:

  1. In infectious lesions of the respiratory system, as well as soft tissues, Azithromycin 500 mg tablets are indicated once a day for three days.
  2. With borreliosis (Lyme disease), you need to drink 2 tablets on the first day of treatment, and then 500 mg once a day. The duration of therapy is five days, the maximum dosage is 3000 mg.
  3. With infectious lesions of the genitourinary system, 1000 mg is shown at one time.
  4. In case of acne, one tablet should be taken for three days. Then a break is made, and on the eighth day from the start of treatment, the treatment regimen is repeated for two months.

Elderly patients take the medication according to the standard scheme, without making any adjustments. And also dosage changes are not required for patients with impaired renal function.

During pregnancy and lactation

According to the results of studies, it was found that the active component of Azithromycin crosses the placental barrier. Given this fact, this drug is prescribed for treatment only if it is impossible to choose a similar remedy, and the benefit from the use will be significantly higher than the possible harm. Also, substances can penetrate into milk, so breast-feeding should be stopped during treatment.

Drug interaction

The simultaneous administration of digoxin and digitoxin during treatment with Azithromycin leads to a significant increase in the concentration of cardiac glycosides in the blood, as well as the possibility of progression of glycoside intoxication.

It is possible to enhance the pharmacological properties of warfarin when taken together with azithromycin. It is not recommended to simultaneously take this medication in conjunction with ergot alkaloids derivatives.

And it was also found that when combined with macrolides, arrhythmia often develops. As a result of the simultaneous administration of Azithromycin with disopyramide, cases of development of ventricular fibrillation were identified.

Concomitant use of the drug with lovastatin can cause the progression of myopathy.

Combined use with cyclosporine significantly increases the risk of side effects and toxic reactions.

Azithromycin Compatibility with Alcohol

The instructions for use do not contain any indications of the compatibility of azithromycin with alcoholic beverages. However, this does not mean that such a combination is permissible. During therapeutic treatment, it is strictly not recommended to drink alcohol. Otherwise, the absorption of the drug is significantly reduced. Given the properties of azithromycin, this leads to a violation of its accumulation in the tissues and a direct effect on the focus of infection. The patient will need a longer course of treatment or taking strong antibiotics, which can also lead to the development of side effects.

Contraindications, side effects and overdose

In some cases, taking azithromycin tablets may be contraindicated.

The use of the drug in such pathological processes is not allowed:

  • inadequate reaction of the body to certain components of the drug;
  • impaired liver function;
  • renal failure;
  • therapeutic treatment with ergotamine.

And also under the ban tablets Azithromycin for children under 12 years of age.

The states of patients in which this drug must be used with extreme caution are noted. In the treatment of antidepressants, hepatic dysfunction of the middle stage, arrhythmia, bradycardia and myasthenia, a consultation with the attending physician and careful monitoring of blood counts are required.
As a rule, the use of antibiotic drugs is always accompanied by various undesirable reactions from the body.

TherapyAzithromycin can cause the following side effects:

  1. Attacks of vomiting and nausea, pain in the stomach, flatulence, upset stool, gastrointestinal tract mucosa, increased salivation, diarrhea, belching, pancreatitis, dysphagia, dyspepsia. And extremely rarely - a change in the color of the language.
  2. Oral candidiasis, pharyngitis, respiratory complications, rhinitis.
  3. Heart palpitations, periodic decrease in pressure, neutropenia, hemolytic anemia.
  4. Dizziness, impaired spatial orientation, migraines, anxiety attacks, sleep disturbances, loss of taste, attacks of aggression, myasthenia gravis and convulsions.
  5. It is extremely rare - visual and hearing impairment, discomfort during urination, arthritis, anaphylactic shock, nosebleeds, hepatitis, urticaria, back and lumbar pain.

The occurrence of any described adverse reactions is a serious reason for drug withdrawal. However, it is not recommended to replace the remedy yourself.

In case of an overdose, an increased manifestation of adverse reactions is noted, in particular, attacks of nausea and vomiting occur. In a similar situation, individual symptoms are treated.

Antibiotic Analogs

 

Azithromycin, synonymous with therapeutic drugs, includes Azimycin, Azitrox, Azimed, Azitral and Azitsin. But these analogues are contraindicated in patients with increased susceptibility to macrolides.

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