Arthrosan tablets are described in the instructions for use as a non-hormonal pharmacological agent designed to reduce inflammation in articular pathologies, accompanied by pain and fever.
Material Content:
- 1 The composition of the drug
- 2 Pharmacological action and pharmacodynamics
- 3 What helps Arthrosan
- 4 Instructions for use of tablets 7.5 mg, 15 mg
- 5 During pregnancy and lactation
- 6 Contraindications, side effects and overdose
- 7 Which is better, Arthrosan tablets or injections
- 8 Analogues of the drug
- 9 Interaction with other medical facilities
- 10 special instructions
The composition of the drug
Tablets containing 15 and 7.5 mg of the treating substance are one of two pharmaceutical forms of anti-inflammatory drugs. The therapeutic basis of the drug is meloxicam. From 1 to 5 contour blisters are placed in a paper bundle, each of which includes 10, 15 or 20 round yellow or yellow tablets, which have a separation risk.
Additional components provide filling, preservation, stability of the drug.
Pharmacological action and pharmacodynamics
The therapeutic substance Arthrosan is a derivative of enolic acid, which belongs to the group of oxycams.
The analgesic effect of pharmaceuticals from the NSAID class, as well as its anti-inflammatory activity and the ability to eliminate fever, are due to the fact that meloxicam selectively suppresses cyclooxygenase (COX-2), which activates the production of prostaglandins (PG) in the inflammation zone - physiologically active substances that increase sensitivity nerve receptors for pain stimuli.
Due to selective blocking of cyclooxygenase-2, the medication rarely provokes erosion, ulceration of the digestive organs.The inhibitory effect of Artozan on the COX-1 enzyme, which is involved in the biosynthesis of GH, supporting the protection of the mucous tissue of the gastrointestinal tract and regulating the blood circulation in the kidneys, is less pronounced.
The pharmaceutical product is actively absorbed from the digestive system, while almost 90% of the treating substance reaches the pathological focus. Simultaneous consumption of products does not affect the intensity of absorption of meloxicam.
The maximum content of a therapeutic substance in plasma is recorded 5-6 hours after internal administration. The equilibrium state (C ss) is observed on the 4-5th day of regular use of the medication. In articular fluid, the concentration of meloxicam is half its maximum amount in the blood.
In people over 65 years of age, the rate of cleansing and removal of the active substance from the body decreases, but renal-hepatic pathologies within the framework of moderate manifestations do not significantly affect the level of its excretion.
It is removed during bowel movements and urination in approximately equal volumes, and mainly in the form of inactive intermediates. The time of elimination of half the dose of medicine received in the body is 15-19 hours.
What helps Arthrosan
Arthrosan helps to alleviate or relieve manifestations in inflammatory and dystrophic diseases of the joints and muscle tissues:
- osteoarthrosis of the spine;
- deforming arthrosis, including - of unclear origin;
- arthritis, including the rheumatoid form of polyarthritis;
- ankylosing spondylitis (ankylosing spondylitis);
- muscle and joint pain of a different nature;
- diseases of the musculoskeletal system accompanied by pain.
It should be clearly understood that the use of Arthrosan tablets helps as part of symptomatic therapy - that is, the medicine eliminates or mitigates painful and inflammatory signs, but does not eliminate the cause of the pathological manifestations. Therefore, it is necessary to diagnose and treat the underlying disease that causes symptoms that are painful for the patient.
Instructions for use of tablets 7.5 mg, 15 mg
Arthrosan should be taken once a day with food, washed down with a sufficient volume of liquid (but not less than 100 ml). This prevents the development of adverse events in the stomach and intestines.
Recommended dosages:
- Arthritis, ankylosing spondylitis - once 15 mg per day. If the level of pain and the degree of inflammation is significantly reduced, the dose can be reduced to 7.5 mg. It is advisable for age patients to limit the daily amount of the drug to a minimum of 7.5 mg.
- With exacerbation of osteoarthritis, osteochondrosis and pain against other muscular-articular pathologies, the medication is prescribed in an amount of 7.5 mg. With a mild therapeutic effect, the dose is allowed to be increased to 15 mg per day.
In order to avoid overdose and the development of adverse reactions, it is not allowed to take more than 15 mg of Arthrosan in 24 hours.
In patients with severe renal dysfunction (CC less than or equal to 25 ml / min) undergoing hemodialysis, the daily amount of meloxicam is limited to 7.5 mg.
The dose with a moderate to low decrease in hepatic function can not be adjusted.
Caution, taking into account the severity of side effects, the medication is prescribed in the following cases:
- patients older than 65-70 years old;
- digestive tract ulcer, Helicobacter pylori infection, diabetes mellitus, peripheral vascular disease;
- ischemia or insufficiency of heart function, damage to cerebral vessels, renal pathology, liver disease;
- patients taking medication for a long time (Diclofenac, Xefocam, Ketoprofen), receiving anticoagulants (Sincumar, Phenilin, Warfarin, Clexane, Fraxiparin, Heparin), diuretics, antiplatelet agents (Aspirin, Curantyl, Plavix), tromiborisol (thrombolithin), thromborolithin Dexamethasone, Prednisolone), SSRI antidepressants (Fluoxetine, Prozac, Escitalopram, Paxil, Zoloft, Citalopram, Fevarin);
- patients with diagnosed dehydration after extensive surgery.
To reduce the possible ulceration of the mucous membrane of the stomach and intestines in the above conditions, the medicine is prescribed in a short course at the lowest dose sufficient for the manifestation of a therapeutic effect.
During pregnancy and lactation
A medication is prohibited for the treatment of nursing patients and pregnant women.
Arthrosan, like other medications that suppress the production of GHGs, can affect fertility and the ability to conceive, and therefore undesirable for the treatment of patients planning a pregnancy.
Contraindications, side effects and overdose
Pharmaceuticals may not be prescribed under the following conditions:
- intolerance to any component of the drug, including galactose and glucose;
- pregnancy, breastfeeding;
- partial or complete combination of intolerance to acetylsalicylates (or NSAIDs) with bronchial asthma and periodically worsening polyposis of sinus sinuses;
- exacerbation of ulcerative colitis, gastrointestinal ulcers, Crohn's disease;
- cerebral hemorrhage, bleeding in the digestive tract;
- age up to 15 years;
- clinically severe myocardial, liver, or renal failure (with CC less than 30 ml / min in patients without hemodialysis);
- diagnosed hyperkalemia;
- lactase deficiency;
- early postoperative period after coronary artery bypass grafting.
The main undesirable effects are observed at different frequencies, decreasing with a decrease in dosage.
| Incidence of adverse events | ||
|---|---|---|
| 1 - 9 out of 100 patients | 1 out of 100 or less | 1 patient out of 1000 and less |
| Heartburn, nausea, dry mouth; Loose stools, constipation; Pain in the abdomen and head; Gas formation, belching, Anemia, itching, skin rash; ·dizziness; Swelling of the extremities; Bronchospasm in patients with asthma | Esophagitis, colitis, ulceration of the gastrointestinal tract; internal bleeding; Stomatitis, conjunctivitis, hepatitis, urticaria, auditory disorders, lethargy; · Increased heart rate, increased blood pressure, redness of the skin on the face; · An increase in blood levels of urea, liver enzymes, creatinine, bilirubin, a decrease in the number of leukocytes and platelets | Vomiting, intolerance to light; Erythema, blisters on the skin, Stevens-Johnson syndrome, epidermal necrolysis; Bronchospasm in patients without asthma, Quincke's edema, anaphylactic reaction; · Instability of the psyche, impaired perception and vision; Acute renal dysfunction |
If a patient has acute side effects, especially vomiting, facial swelling, anaphylactic reaction, severe itching of the skin and jaundice, dark urine, neurological disorders, you should immediately stop taking Arthrosan and seek help from a specialist. Severe conditions require an emergency call "ambulance".
In case of overdose observed:
- vomiting, loss of consciousness;
- pain in the epigastric zone, signs of bleeding;
- kidney failure, liver;
- shortness of breath, pressure drop.
The patient is urgently hospitalized for gastric lavage and intensive treatment.
Hemodialysis and forced diuresis do not give a positive result.
Which is better, Arthrosan tablets or injections
Intramuscular injections Arthrosan is a fast-acting form of the drug used to relieve acute painful and inflammatory attacks, since the analgesic effect with injection is faster and more pronounced. Solution for injection can be done exclusively in the muscle.
Most often, injections are prescribed in the first days of therapy, then moving on to the internal intake of tablets. Meloxicam in injections is characterized by a greater severity of side effects, and long-term use of injections leads to the fact that the pills begin to have less analgesic effect.
Do not be fooled that tablets, getting into the stomach, cause gastrointestinal problems, and the solution does not.Adverse reactions occur regardless of the form of use of the pharmaceutical.
Analogues of the drug
Analogues of arthrosan tablets with an identical therapeutic substance: Movalis, Genitron, Amelotex, Mirlox, Meloxicam, Movasin, Bi-xicam.
Other non-steroidal medicines that relieve pain and inflammation, but with other active substances: Xefocam, Diclofenac, Celecoxib, Artoxia, Nimesulide, Rofecoxib (Denebol), Ketoprofen.
Interaction with other medical facilities
Arthrosan when combined with other drugs is able to:
- enhance the effect of drugs that lower blood sugar;
- weaken the hypotensive effect of drugs that lower blood pressure;
- increase the toxicity of digoxin, antibiotic aminoglycosides, as well as lithium preparations by increasing its concentration in the blood;
- weaken the diuretic effect of diuretics, increasing the likelihood of developing renal dysfunction;
- reduce the effectiveness of intrauterine contraceptives;
- enhance the side effects of methotrexate, accelerating the development of anemia, leukopenia.
It should also be borne in mind that Arthrosan increases the risk of:
- bleeding in parallel with thrombolytics, anticoagulants, antiplatelet agents, antidepressants of the SSRI group;
- renal failure when combined with the immunosuppressant cyclosporin;
- ulceration and erosive lesions of the mucous membrane of the stomach and intestines, bleeding in the gastrointestinal tract with combined use with other NSAIDs (including Aspirin and any medicine with acetylsalicylic acid).
Cholestyramine and antacids with aluminum (Almagel, Gastracid, Maalox) weaken the absorption of meloxicam.
special instructions
Patients receiving arthrosan and diuretic medications should drink more fluids.
After 10-14 days of administration, you need to monitor the level of liver enzymes, kidney function, blood coagulation (with parallel treatment with anticoagulants and antiplatelet agents).
Meloxicam can mask the manifestations of infectious pathologies.
In cases of occurrence of undesirable side effects such as dizziness and lethargy, the patient should be especially careful when driving, performing work on hazardous equipment, activities where concentration and speed of reactions are required.
