Suspension "Amoxicillin" is one of the most famous and most used antibiotics. It is used to treat various diseases caused by pathogenic bacterial flora. The suspension has a pleasant taste and smell, so it is easy to give it to young children. This avoids tantrums and painful injections in the future.

The composition of the drug

Granules for the preparation of a suspension contain the main active ingredient amoxicillin trihydrate and auxiliary components that give the medicine color, taste, smell, and also protect against premature destruction by gastric juice.

These include:

  • aerosil;
  • calcium stearate;
  • carmuazine;
  • sodium citrate;
  • aspartame;
  • sodium benzoate;
  • vanilla or strawberry flavoring;
  • sugar.

It is important to consider the presence of sweeteners when prescribed to people who have impaired glucose tolerance (diabetes mellitus). Also, allergic reactions may develop due to flavorings, so patients with a tendency to allergies should take the drug with caution.

The finished suspension may contain 250 mg / 5 ml or 500 mg of amoxicillin, depending on its initial concentration, which is indicated on the package.

Pharmacological properties and pharmacokinetics

The precursor of the drug is Ampicillin, but there is no hydroxyl group in its composition.Therefore, Amoxicillin is better absorbed from the gastrointestinal tract and has greater bioavailability when used orally.

The antibiotic Amoxicillin has an extensive spectrum of action, that is, a large number of different bacteria fall under its influence.

This allows you to use the drug with a huge number of infections caused by:

  • gram-positive cocci - staphylococci, streptococci of various groups;
  • gram-negative cocci - n. Gonorrhoeae, n. Meningitidis;
  • Gram-negative sticks - Salmonella, Escherichia coli, Shigella, Chlamydia.

The medicine belongs to the semisynthetic series of penicillins, therefore its main effect is based on the inhibition of cell membrane synthesis, as a result of which pathogenic microorganisms cease to function and die.

Amoxicillin has almost instantaneous and very high absorption - more than 90% of the active substance enters the bloodstream.

Eating does not affect the absorption of the drug in the stomach, because thanks to the hydroxyl group, the acidic environment practically does not destroy it. After using the product, its maximum concentration in the blood can be observed after 1 - 2 hours.

In addition, Amoxicillin has a large distribution spectrum - in a therapeutically significant dosage, it is found in:

  • sputum and serous secretion of the bronchi (with purulent discharge from the respiratory tract is inactive);
  • pleural fluid;
  • blood plasma;
  • the contents of skin rashes;
  • bile;
  • middle ear;
  • urine
  • intestinal mucosa;
  • fat cells;
  • the body of the fetus;
  • lungs;
  • bones;
  • ovaries, uterus, bladder.

Such a distribution spectrum allows the use of Amoxicillin for lesions of different localization.

However, not all diseases require an oral antibiotic, sometimes a local effect is sufficient - in such cases, other forms of amoxicillin are used.

What diseases are prescribed Amoxicillin suspension

An antibiotic is able to inactivate many different microorganisms, so it is widely prescribed for the treatment of various diseases:

  1. Respiratory tract lesions: otitis media (middle ear), sinusitis (sinuses), bronchitis, pneumonia, tonsillitis, pharyngitis (pharynx).
  2. Gastrointestinal tract lesions: peritonitis, cholecystitis, intestinal infections.
  3. Lesions of the urinary system: pyelonephritis, urethritis, glomerulonephritis;
  4. Purulent lesions of the soft tissues.

In severe infections, the antibacterial drug is administered intravenously. A suspension of "Amoxicillin" is prescribed for non-life-threatening diseases, for example, with angina, otitis media, cholecystitis.

The antibiotic is used for combination therapy of chronic gastritis and stomach ulcers. Amoxicillin and Metronidazole are introduced into the treatment regimen. Together, they prevent the propagation of pathogenic flora and kill microorganisms.

Instructions for use for adults and children

The drug is used internally, regardless of the use of food.

The dosage of Amoxicillin and the frequency of administration is determined by the severity of the disease, the age and weight of the patient:

  • children after 10 years and adults (body weight 40 kg or more) - 500 mg three times a day, in extreme cases, a single dose is allowed to be increased to 1000 mg;
  • 5-10 years - 250 mg three times a day;
  • from 2 to 5 years - 125 mg three times a day;
  • up to 2 years of age, the dose is calculated on the weight of the baby - 20 mg / kg in three doses during the day;
  • up to 3 months - no more than 20 mg / kg per day in two doses.

In the treatment of premature babies, the dosage should be reduced, and the interval between doses should be increased.

The duration of treatment is from 5 to 12 days. It is important not to stop drinking the medicine even after the symptoms disappear, otherwise the disease will return quickly and stronger antibiotics will be needed.

In the instructions for use of Amoxicillin, standard doses are indicated, but the attending physician can adjust them and adjust them to the selected treatment regimen.

It must be borne in mind that the concentration of the active substance may be different. The most commonly used dosage is 250 mg / 5 ml of the drug, or one scoop that is attached to the medication.

To prepare the suspension, you need to boil and cool to room temperature a small amount of water, then add it to the bottle to hell and shake the jar well. Amoxicillin should be bred immediately before the first dose, the prepared product can be stored in the refrigerator for two weeks. Before each use, the medicine should be thoroughly shaken to raise solid particles from the bottom of the vial.

During pregnancy and lactation

"Amoxicillin" is able to pass through the placenta, but there have been no cases of negative effects on the fetus. The drug is prescribed for expectant mothers when there is no way to choose alternative methods of treatment. You should not drink the antibiotic on your own, due to the high risk of developing adverse reactions.

During lactation, it is not recommended to use Amoxicillin, since the active components of the drug pass into breast milk, and with it, into the baby’s body. Because of this, the baby may have problems with the intestinal microflora, and in the future severe infections may be caused by antibiotic-resistant microorganisms.

Amoxicillin Alcohol Compatibility

Like any other antibiotic, Amoxicillin is absolutely not compatible with alcohol. Firstly, alcohol accelerates the elimination of the drug from the body, which is why it does not have time to affect harmful bacteria. Secondly, both alcoholic drinks and antibacterial agents have a negative effect on a person, which is significantly aggravated with simultaneous use.

Possible consequences of taking alcohol during therapy:

  • overload of the liver and kidneys, since both substances are excreted with their help, the development of organ failure, as well as tissue necrosis;
  • bowel disorder;
  • respiratory arrest, stroke;
  • sudden cardiac arrest, heart attack.

You can drink when amoxicillin is completely eliminated from the body. Healthy kidneys and liver usually need about 8 hours to completely cleanse the blood.

Drug interaction

"Amoxicillin" interacts not only with alcohol, there are a number of drugs that are also undesirable to drink simultaneously with this antibiotic. In the best case, the drugs simply neutralize the effect of each other, at worst they can cause the development of serious consequences.

  • phenylbutazone, sulfinpyrazone, probenecid, acetylsalicylic acid - increase the excretion time of amoxicillin and increase its concentration in plasma;
  • oral contraceptives - an antibiotic reduces their effectiveness, making conception possible;
  • allopurinol - the appearance of a rash on the skin;
  • methotrexate - increased toxic effect of drugs;
  • lansoprazole - causes inflammation of the tongue, oral mucosa.

To avoid unwanted interactions, it is necessary to warn the attending physician about medicines that the patient is already taking or has been taking recently.

Contraindications, side effects and overdose

Amoxicillin is widely used in medical practice, since it has a rather small list of contraindications:

  • individual intolerance to the components of the drug;
  • a history of atopic dermatitis;
  • attacks of bronchial asthma in the past;
  • the development of colitis after taking antibiotics;
  • fructose intolerance;
  • Infectious mononucleosis.

In case of non-compliance with the rules of admission or ignoring contraindications, the development of adverse reactions of the body is possible. They usually do not require additional treatment and pass on their own after discontinuation of the drug.

Undesirable effects include:

  • disorders of the stool, inflammation of the oral cavity, a change in taste perception;
  • itchy rashes, urticaria, dermatitis, Quincke's edema, anaphylactic shock;
  • accelerated heartbeat, passing anemia, a decrease in the concentration of platelets in the blood;
  • headaches, cramps, disorientation.

Often, due to the use of Amoxicillin, vaginal candidiasis or candidal stomatitis, dysbiosis develops.

For prophylaxis, probiotics and local antimycotic agents are prescribed simultaneously with an antibiotic.

If you accidentally or intentionally take large doses of Amoxicillin, overdose symptoms develop - dehydration, neurotoxicosis, thrombocytopenia, the appearance and exacerbation of side effects. In such situations, the body needs help to remove the poison. For this, gastric lavage is performed, saline laxatives and activated charcoal are given, droppers are placed, hemodialysis is performed.

Antibiotic Analogs

Amoxicillin has many analogues - more expensive or cheaper, in a different medical form, with a different taste, with a different concentration. But all of them are united by the active substance - amoxicillin trihydrate.

An experienced doctor will help you choose an analogue.

The most famous alternatives are:

  • "Flemoxin Solutab";
  • Amosin
  • Purimox
  • Amoxisar
  • Ospamox.

Suspension "Amoxicillin" for children is an excellent treatment option for bacterial infections, which avoids painful injections and bitter tablets. Thanks to its pleasant taste, it is easy to drink it for small children who take medicine for a treat.

Similar:More from the author: