You cannot tolerate acute pain: you must immediately take measures to eliminate it. Many as an "ambulance" resort to the drug "Nimesulide." How it affects the body, the properties of the active substance, especially the use - about this in the article.

Forms of release, composition

The drug has one active component - N- (4-Nitro-2-phenoxyphenyl) methanesulfonamide or nimesulide, a substance in the group of non-steroidal anti-inflammatory drugs.

 

You can use different forms of medication:

  • granules for solution preparation - 100 mg of nimesulide in a bag;
  • tablets - 100 mg;
  • suspension - a bottle of 60 ml;
  • gel - 0.1%.

Auxiliary components for each form of the drug are different. They help increase the shelf life of the medicine, improve its taste and structural characteristics.

Pharmacological action, pharmacodynamics and pharmacokinetics

A characteristic feature of sulfonylamides, to which the drug belongs, is the ability to quickly block pain receptors. This effect is achieved by influencing the synthesis of prostaglandins through the enzyme cyclooxygenase.

The most pronounced anesthetic and anti-inflammatory effects of the drug. But reduces the heat of nimesulide is not as effective as many other NSAIDs. And it is forbidden to take it with a fever of an infectious genesis or during a cold.

The absorption of oral forms of the drug occurs very quickly: it begins immediately in the oral cavity through the mucous membrane. The maximum plasma concentration is observed after one and a half to two hours.The duration of action is up to 6-7 hours.

The gel is quickly absorbed and almost instantly anesthetizes the affected area. It hardly enters the bloodstream. The substance is excreted in the form of liver metabolites and unchanged by the kidneys.

Why is Nimesulide prescribed?

The drug does not cure the disease, but relieves acute pain symptoms, reducing signs of inflammation.

Most often, Nimesulide is used for pathologies of the musculoskeletal system, causing acute pain.

Among them:

  • arthritis of various origins;
  • osteoarthritis, arthrosis;
  • osteochondrosis;
  • rheumatism;
  • radiculitis;
  • bursitis.


Also, the medicine is used for other pathologies accompanied by acute pain syndrome.

It:

  • toothache (acute and after treatment);
  • neuralgia;
  • post-traumatic sensations;
  • arthralgia;
  • headache;
  • myalgia;
  • postoperative pain;
  • stretching and inflammation of the muscles, tendons;
  • painful periods.

In addition, the gel is used for:

  • tendonitis;
  • lumbago;
  • sprain of muscles;
  • osteoarthritis;
  • periarthritis.

Instructions for use and dosage

Any form of the drug is available only to patients who have reached the age of 12 years. Drinking at an earlier age is fraught with serious complications.

 

The dosage should be selected the smallest, which is effective. The course of admission should not be continued for more than 14 days.

Nimesulide tablets

Pills should be taken after eating, so as not to irritate the mucous membrane. The recommended daily intake for adults is 200 mg of the drug. It must be divided into two methods. Maximum - 400 mg per day. Children after 12 years should take 50-100 mg of the drug twice a day.

In powder form

Before use, the granules should be dissolved in half a glass of clean water (can be cold or slightly heated). Drink immediately, do not store the solution.
The dosage of Nimesulide in the powder is the same as in the tablet form: 1 sachet (100 mg of active substance) 2 times a day. Adult patients, if necessary, can increase the dose to 400 mg per day, not more. For elderly patients, the doctor chooses the correct dosage, focusing on well-being and clinical indicators.

Gel Nimesulide

For local relief of pain, the ointment structure of the drug is suitable. It is necessary to squeeze 5-6 cm of the gel from the tube and gently rub into the affected area until completely absorbed. The procedure can be performed 3-4 times a day for no more than a month.

Do not use the drug on open wounds or in places near the eyes and lips. If accidentally swallowed, rinse your mouth and take sorbents.

During pregnancy and lactation

Pregnant women are most at risk of catching various diseases. After all, immunity in this state is often weakened.
Elevated temperature, body aches, pain of various origins are signs of the onset of the inflammatory process. Is it possible to eliminate them with the help of Nimesulide?

Doctors do not advise starting such treatment, because the drug is too strong. Doctors recommend weaker remedies of the same action.

In the first trimester, when all fetal systems develop, the drug can cause pathologies. It is possible to use the medicine in the second trimester, when the child’s organs have already formed, but only under the supervision of a doctor.

And taking the medication in the last trimester threatens with serious complications for the mother and fetus:

  • pressure drops, threatening premature birth;
  • renal failure;
  • the likelihood of premature closure of the ductus arteriosus;
  • water reduction;
  • stop uterine contractions;
  • bleeding
  • edema.

 

During lactation, Nimesulide should also not be used for pain relief. The substance passes into milk and has a negative effect on infants.

Can I drink alcohol while taking the drug

The drug does not enter into direct interaction with ethyl sleep, so the manufacturer's instructions do not report anything about the possibility of combination.

Medicine has a strong belief about this issue: the simultaneous use of alcohol and a potent anti-inflammatory drug does not cure, but cripples the human body.

Why are doctors so categorical? Drinks containing ethyl alcohol have a detrimental effect on cells and tissues of all organs, especially on the main filter - the liver. It is destroyed by alcohol. "Nimesulide" is a very toxic drug, it also significantly increases the load on the liver. A cocktail, which is obtained when combined, causes severe malfunctions in the liver, which can result in complete dysfunction and hepatitis.
Therefore, you need to take a pill only when at least 10 hours have passed after the last glass of drunk alcohol. Otherwise, the expected effect will not be, but only complications will appear.

Drug interaction

  • Other NSAIDs when taken together with the drug cause an aggravation of toxic effects. This should not be done!
  • If you take glucocorticosteroids and antithrombotic drugs with the discussed drugs, the likelihood of internal bleeding in the digestive tract increases.
  • Nimesulide reduces the effectiveness of diuretics and furasemide, along with the latter drug complicating the withdrawal of potassium and sodium.
  • Lithium-containing drugs increase the negative effect on the body if you use them together with drugs.
  • The drug reduces the effectiveness of hypertensive and antiarrhythmic drugs.
  • Nimesulide along with ACE inhibitors often provokes the development of renal failure.
  • The drug with cyclosporine causes an increased load on the kidneys and liver, which causes their dysfunction.

The described combination refers to oral preparations that have a systemic effect on the body. The gel does not react with other drugs with proper use and dosage.

Contraindications, side effects and overdose

The high effectiveness of drugs is due to the fact that nimesulide is a powerful substance in its effect on the body.

That is why, eliminating undesirable symptoms in the form of fever or acute pain, it at the same time has an effect on other body systems. Side effects are periodically observed in patients taking the drug.

The list is impressive:

  • the urge to vomit;
  • acute pain in the stomach;
  • diarrhea or constipation;
  • myocardial rhythm disturbance;
  • heart rate jumps;
  • general weakness, fatigue;
  • increased plasma potassium;
  • swelling of the skin;
  • frequent dizziness;
  • a sharp increase, and then a decrease in blood pressure;
  • allergic skin rash, scabies;
  • uncontrolled muscle cramps;
  • hyperhidrosis;
  • breathing problems, shortness of breath;
  • cramping in the bronchi;
  • increased gas formation;
  • ulcerative pathology, erosion, bleeding in the digestive tract;
  • inflammation of the liver;
  • urination disorders;
  • sores in the mouth, gums;
  • vision problems;
  • panic syndrome;
  • anxiety;
  • renal failure;
  • decline in temperature indicators;
  • excessive activity, aggressiveness.

Such symptoms are most often observed after taking tablets or suspension. The gel does not enter the bloodstream when used correctly, so the risk of side effects is minimal. At the place of application of the ointment, allergic reactions are possible: redness, rash and peeling of the dermis.

To reduce the level of toxic effects on the body, you should take the drug in the lowest effective doses in a short course.

Failure to comply with the recommended dosage leads to serious consequences. In this case, side effects are exacerbated, and there is also the likelihood of acute renal failure, respiratory arrest, anaphylactic shock, seizures, and coma. In case of an overdose, it is necessary to take sorbents and immediately call a doctor.

Overdose when using the gel can only occur in the case of a significantly higher dose of the drug (more than 50 g). Signs of the condition are nausea and vomiting.

 

High toxicity of the drug causes a large number of contraindications.

It:

  • hypersensitivity to components (active and auxiliary), other NSAIDs;
  • aspirin asthma - allergy to acetylsalicylic acid;
  • children's age - up to 12 years;
  • diseases with internal bleeding;
  • decompensated heart failure;
  • severe liver pathology;
  • decreased blood clotting;
  • pregnancy (in the first and last trimester);
  • ulcerative processes in the stomach;
  • the period after coronary bypass surgery;
  • lactation;
  • fever and fever with viral diseases and acute respiratory infections;
  • hyperkalemia
  • alcoholism and drug addiction.

Also, when prescribing the drug, one must take into account the presence of the following diseases requiring dose adjustment and careful observation by a doctor:

  • problems with kidney function;
  • arterial hypertension;
  • type 2 diabetes mellitus;
  • ischemia.

Treatment of elderly patients requires regular monitoring, visual and clinical, if necessary, dose reduction or drug withdrawal.

Analogs of Nimesulide

Complete synonyms of the drug are presented in pharmacology with various medicines with nimesulide in the composition.

Among them:

  • "Nemulex" in granules for a medical solution;
  • "Flolid" in tablets, suspensions and granules;
  • "Nimesan" in tablet form;
  • "Actasulide" in capsules;
  • "Prolide" - absorbable tablets;
  • “Nise” in the form of tablets, gel and suspension;
  • "Nimesil" in granules;
  • Aponil in pills;
  • "Nimulide" - granules, tablets, ointment.

Similarly, other NSAIDs act on the body, eliminating pain, fever and blocking the development of inflammation. The range of medications is wide, since there are many synonymous series of drugs with the same active substance.

The choice of a particular medication, as well as its form, depends on the specific situation - symptoms, diagnosis, age and the presence of other pathologies in the patient.

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