A strong anti-inflammatory, analgesic and antipyretic agent is in demand in rheumatic diseases, toothache, and colds. Most adults pay attention to the safety of this group of drugs. The researchers’s conclusion is encouraging that the Nimesil analogues are well tolerated and rarely cause serious side effects with prolonged use.
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Composition (active substance) of NSAIDs
Nimesulide is an active ingredient in a number of modern non-steroidal anti-inflammatory drugs (NSAIDs), including Nimesil.
The medicine combines a powerful analgesic and anti-inflammatory effect.
Nimesil is available in the form of soluble granules. One sachet for a single dose contains 100 mg of the active substance. The composition contains auxiliary components, including sugar, citric acid, flavor. A suspension is prepared from the powder for oral administration.
Nimesil manufacturing companies are located in Spain, Germany, Italy. The price of imported drugs in a pharmacy is from 660 to 750 rubles per package (30 pcs.), 300 rubles (9 pcs.). The cost of one bag is 24 rubles. If you take into account the advantages of nimesulide and a soluble form of release, then the price does not seem to be too high. However, you can find cheaper analogues - domestic or imported.
Nimesulide belongs to the group of selective non-steroidal anti-inflammatory drugs (NSAIDs), selectively affects the cyclooxygenase enzymes involved in the synthesis of prostaglandins. Inhibition of COX leads to a weakening of pain and other symptoms of inflammation.
The selectivity of the action of nimesulide reduces the risk of heart attack and gastrointestinal bleeding.
The active ingredient is completely absorbed in the digestive tract, distributed in the synovial fluid, lasts longer than in the blood. These features allow the drug to act quickly after ingestion, to develop a powerful analgesic effect and last longer.
Cheap Russian Nimesil analogues in powder
Domestic manufacturers produce drugs in soluble form. There is not one complete analogue of Nimesil in powder, in particular, these are Russian preparations Nemuleks, Nise, Nimesulide-SZ, Naysulide. Single-dose sachets contain 100 mg of nimesulide in the form of soluble granules.
It is more likely to find in pharmacies the means of Russian manufacturers - Nemulex (Sotex), Nise (Canonpharma), analogues in the form of dispersible tablets. When dissolved, the same result is obtained as when mixing Nimesil granules with water.
Price of Nemulex powder:
- 10 sachets - from 210 rubles;
- 30 sachets - from 570 rubles.
The cost of packaging "Nise" (9 sachets) - from 270 rubles. In the latter case, the price differs from the cost of Nimesil by 20-30 rubles.
Similar domestic drugs in tablets
On the pharmacy shelves, the analogue of Nimesil is not difficult to find in tablets, usually these are drugs manufactured by Russian pharmaceutical companies. They contain the active ingredient in a dosage of 100 mg.
Relatively cheap tablets with nimesulide in Russia are produced by the companies Ozone, Izvarino Pharma, ABBA, Berezovsky Pharmaceutical Plant, and Marbiopharm. The average price is from 160 rubles (20 pcs.).
Complete overseas structural substitutes
In the West, many drugs are produced with the active substance nimesulide. Complete structural substitutes contain it in an amount of 100 mg. Reasonable prices for Nimesulide-Teva tablets - 155 - 185 rubles.
Many structural analogues are released in India. This is the drug "Nimulide" in the form of:
- suspension for oral administration - 180 rubles;
- oral tablets - 365 rubles;
- lingual tablets for resorption under the tongue - 275 rubles.
Also in India, they produce Nimika tablets (235 rubles), Nimesan tablets (165 rubles), Nise (175 rubles).
“Nise” is also the name of the gel. They produce drugs with a concentration of nimesulide of 1 and 2% (215 and 315 rubles, respectively). An analogue in composition and mechanism of action is Nimulid (265 rubles). Gels are used externally to relieve pain, reduce stiffness in the morning and increase joint mobility.
Nimesil's analogs in therapeutic action
Other NSAIDs have analgesic and anti-inflammatory effects: Diclofenac, Naproxen, Ibuprofen. However, only Nimesil and Meloxicam are considered selective drugs in their pharmaceutical group. Analogues of Nimesil for therapeutic action are prescribed to relieve inflammation and pain of various origins.
The choice of a group analog is best entrusted to a doctor. Each NSAID has application features and, in addition to the main ones, has additional effects on the body.
The most affordable and relatively safe substitutes for Nimesil:
- "Paracetamol". This is a first line medicine in pediatrics. It can be taken during pregnancy and lactation. The antipyretic and anti-inflammatory effect of the drug is better expressed, the analgesic effect is less pronounced. Trade names of the preparations: “Panadol”, “Migrenium”, “Efferalgan”, “Cefecon D”, “Solpadein”. Paracetamol, like other NSAIDs, is best taken in a short course. You can replace it with a combination drug with ibuprofen. The commercial name is Ibuklin, Next, Brustan.
- Ibuprofen. The tool quickly has an antipyretic and analgesic effect. Subject to dosages and frequency of use, it does not damage the gastrointestinal mucosa and the functions of the cardiovascular system.Trade names: "Nurofen", "MIG 400", "Faspik", "Long cream", "Deep Relief".
- Tempalgin. The combined preparation contains NSAIDs metamizole sodium and tempidone. This combination enhances the analgesic effect, has a calming effect. Anti-inflammatory and antipyretic properties are less pronounced. Trade names of other painkillers with metamizole: “Analgin”, “Spazmalgon”, “Pentalgin-N”, “Sedal-M”.
Tempalgin suppresses inflammatory mediators in tissues, prevents the spread of information about pain in the central nervous system. They take pills for different types of pain: headache, toothache, menstruation, colds, migraines, intestinal and renal colic.
Some NSAIDs better help with fever, while others are more in demand with inflammation and pain. The advantage of Nimesil is selectivity, that is, selectivity of action. The drug harms the digestive tract less than other powerful NSAIDs. Nimesil and its analogues are used mainly for the treatment of pain.
