Midokalm is classified as a direct muscle relaxant. For the most part, this medication is used in neurological practice and is recognized to be effective in more than 30 countries. Its main advantages include the fact that Midokalm rarely provokes side effects, and also does not provide a sedative effect and does not affect the ability of patients to do anything that requires concentration and a good reaction. But this medicine has a number of restrictions for use, and before proceeding with treatment, you need to read the instructions for use.

Composition (active substance) and release form

The active component of the drug is the compound of tolperisone hydrochloride. The drug is presented in the form of rounded convex tablets with a white film coating and a volume of the active component of 50 and 150 mg, also available in the form of solutions for injection.

The tablet form of the therapeutic agent is supplemented with such substances:

  • citric acid monohydrates;
  • colloidal silicon dioxide;
  • stearin;
  • cellulose microcrystals;
  • corn starch;
  • lactose molecules.

The white coating of the tablets is made of titanium dioxide, colloids of silicon, lactose, macrogol and hypromellose.

The injection solution is a colorless liquid with a characteristic, pronounced odor, poured into glass ampoules with a capacity of 1 ml.

As other components added:

  • lidocaine hydrochloride;
  • monoethyl ether compounds;
  • diethylene glycol;
  • water.

The medicine is suitable for use within 36 months from the date of release. It must be stored in a room with a temperature of 15 to 30 ° C with moderate humidity. You can buy medicine in the pharmacy network only with a prescription certified by the signature and seal of the doctor.

Pharmacological properties and pharmacokinetics

The active substance of Midokalm affects the central nervous system and allows you to reduce muscle tone, reduce the degree of susceptibility and relieve cramping. Due to the analgesic and relaxing effect, the drug helps to facilitate the process of making movements. Moreover, unlike other medicines with a similar mechanism of action, the drug does not affect vitality and clarity of consciousness.

The medication enters the blood through the walls of the digestive tract and is well absorbed by the cells. When using the drug in tablets, the substances reach the maximum concentration in half an hour, and the effect of the application lasts from 4 to 6 hours.

When a solution for injections is used, the medicine reaches a therapeutic maximum in the blood within 30-45 minutes, and the half-life takes about 2 hours.

Metabolism of substances is produced in the cells of the liver and kidneys, and more than 95% of the drug is excreted in the urine, and the remainder in the bile.

What helps Midokalm

The drug is able to have a direct effect on the central nervous system, and is widely used in neurological practices, as well as Midokalm is prescribed in the preoperative period in emergency conditions.

Indications for the use of the drug are such disorders:

  • lesions of the central nervous system, accompanied by increased muscle tone and spasticity;
  • conditions characterized by dystonia of muscle tissue;
  • diseases associated with obliterative processes in the vessels;
  • pathology of the bone and muscle apparatus;
  • neuroinflammatory processes in the brain, accompanied by disorders of muscle functionality and motor activity;
  • impaired functionality of large vessels;
  • hemorrhoids occurring against a background of severe pain;
  • pain with gallstone formations;
  • severe menstrual syndrome;
  • colic in the kidneys;
  • disorders of the functions of the musculoskeletal system, including osteochondrosis;
  • uterine hypertonicity during pregnancy.

In addition to these conditions, treatment with Midokalm is carried out after surgical interventions of orthopedic, traumatological and surgical orientation.

Instructions for use of the drug

The treatment regimen of Midokalm and the duration of therapy are determined by a specialist, focusing on the underlying disease, concomitant disorders and individual characteristics of the patient. The form in which the drug will be prescribed depends on the same. Consider the generally accepted methods of using the medication.

Midokalm in ampoules for injections

Injections of Midokalm should be done intramuscularly twice a day. The volume of a therapeutic agent for single use is 100 mg.

If the medication is prescribed for intravenous administration, the dosage remains the same, but injections are given once a day.

Medocalm tablets 50 mg

The drug in tablet form is intended for use after meals. The usual dosage for adults is 1 to 3 tablets of 50 mg three times a day. The total daily volume should not exceed 450-500 mg.

For children, the dosage is calculated based on body weight.

Depending on the age category, the following doses are used:

  • younger than 6 years - at 0.005 g per kg;
  • from 7 to 18 years old - from 0.002 to 0.004 g per kg.

Younger patients should take the medicine once a day.

Mydalm tablets 150 mg

If Midokalm 150 mg tablets are used, they should be drunk 1 piece three times a day. For pediatric patients, the dosage is calculated in the same way as in the previous case.

Typically, therapy is started with 50 mg tablets, drinking them in 1 piece 2 to 3 times a day, and then gradually increase this dose. When the volume of a single dose reaches 150 mg, Midokalm is prescribed with an appropriate mass fraction of the active substance.

Attention! If the doctor has prescribed Midokalm, it is necessary to notify him of concomitant diseases, since there are contraindications to its use. And if the patient is currently taking any medications, this should also be reported to a specialist, as tolpeziron hydrochloride is incompatible with some compounds that make up other drugs.

During pregnancy and lactation

For the use of most medicines, the period of pregnancy and lactation is an absolute contraindication. Midokalm in any dosage forms was no exception. It can be prescribed only when the intended benefit significantly exceeds the possible harm to the woman’s body and the unborn baby.

As a rule, this drug is used in the first months of pregnancy, if the tone of the uterus is greatly increased, and there is a great risk of miscarriage. In this case, the treatment is under medical supervision, and the patient is most often placed in a hospital.

When Midokalm is prescribed in the postpartum period, the child is advised to transfer to artificial feeding.

Can I drink alcohol while taking the drug

Alcoholic beverages do not affect the severity of the therapeutic effects of Midokalm. When treating, it is permissible to combine this medicine with medicinal formulations containing ethyl compounds. Therefore, a ban on the use of alcohol in small doses during drug therapy is not imposed.

However, alcohol abuse should not be allowed, abundant and frequent libations threaten with the following conditions:

  • severe pain in the head;
  • muscle aches and general impotence;
  • nausea and vomiting
  • diarrhea.

In some cases, the joint use of a therapeutic agent with a large amount of alcoholic beverages leads to a rapid decrease in body weight in a significant amount.

Drug interaction

When Midokalm is used for injection, it is forbidden to mix it in the same syringe or dropper with other medicinal solutions.

When using the medicine in any form, care must be taken when combining it with the following groups of medicines:

  • non-steroidal;
  • peripheral muscle relaxants;
  • vegetotropic drugs;
  • psychotropic medicines;
  • agents for general anesthesia.

The fact is that tolperisone is able to enhance the effects of these drugs, after which symptoms of mild overdose may appear.

If you need to drink Midokalm along with other medicines of the same group, you need to reduce its daily volume. Otherwise, the likelihood of side effects is high.

It is allowed to combine this medicine with sedative and hypnotic drugs, since Midokalm alone is not able to provide such an effect and affect the human reaction.

Contraindications, side effects and overdose

Midokalm in any form is prohibited to use in the presence of the following conditions:

  • severe renal and hepatic dysfunction;
  • convulsive manifestations;
  • Parkinson's disease;
  • myasthenia gravis;
  • drug addiction;
  • acute mental illness;
  • severe allergic reactions;
  • intolerance to the components of the drug.

Contraindications for the use of the composition in tablet form include:

  • the period of gestation and feeding;
  • age up to 12 months.

The composition for injection can not be used in the same cases, and it is not administered to children and adolescents under the age of 18.

Side effects during treatment with Midokalm are quite rare, sometimes there is a slight irritation at the injection site if an injection is used.

Not more than 30% of cases, the appearance of the following reactions:

  • sleep disturbances;
  • pain in the head and neck;
  • imbalance in blood pressure;
  • dyspepsia;
  • muscle weakness and pain;
  • appetite and anorexia disorders;
  • general discomfort and decreased vitality.

Significantly less likely to occur such conditions:

  • lymph nodes increase in various parts of the body;
  • anemia develops;
  • consciousness fades from time to time;
  • indomitable thirst appears;
  • sharply reduced heart rate;
  • Symptoms of anaphylactic shock are present.

In less than 5-7% of cases, the appearance of the following symptoms was recorded:

  • noise in the head and ears;
  • nosebleeds;
  • cramps in the stomach;
  • upset stool;
  • urinary incontinence;
  • shortness of breath and shortness of breath;
  • malfunctions in the heart rhythm;
  • motor disorders;
  • convulsive manifestations and tremors;
  • decreased attention span;
  • increased drowsiness;
  • general breakdown;
  • nervous irritability and depression;
  • manifestations of hypersensitivity.

Midokalm is not considered a toxic compound, and even when the recommended dose was much exceeded, overdose symptoms do not always occur. In some situations, convulsions and shortness of breath may appear. If this happens, the patient needs gastric lavage and therapy in accordance with the symptoms that have arisen. It is impossible to ignore such conditions, because in the absence of medical care, the patient's well-being can significantly deteriorate.

Analogues of the drug Midokalm

Medokalm analogues include drugs that have a similar effect, but other compounds are used as active substances.

If a patient is intolerant of tolperisone, it is advisable to treat with one of these drugs:

  • Sirdaludom (with tizanidine);
  • Myolgin (with paracetamol and chlorzoxazone);
  • Lexotan (with bromazepam);
  • Baclofen (with baclofen).

The listed drugs are also able to relieve spasms and hypertonicity, but the advantage of Midokalm is that it has a wide range of effects. In addition, this tool has been known for many years, which can not be said about analogues.

According to experts, the question of replacing Midokalm with other medicines raises quite rarely, since it is well tolerated, and side effects occur only in individual cases.

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