“Lomilan” is a popular drug belonging to the group of antihistamines. The principle of action is based on the mechanism of competitive inhibition of H1-histamine receptors. According to the instructions for use, Lomilan relieves the symptoms of allergic reactions and eliminates exudate in inflammatory processes.
Material Content:
- 1 Composition (active substance) and release form
- 2 Pharmacological action, pharmacodynamics and pharmacokinetics
- 3 Why Lomilan is prescribed for children and adults
- 4 Instructions for use of tablets and syrup
- 5 During pregnancy and lactation
- 6 Drug interaction
- 7 Contraindications, side effects and overdose
- 8 Analogs of Lomilan
Composition (active substance) and release form
“Lomilan” is a medication based on the active substance loratadine. Available in 2 formats: tablets and suspension for the preparation of syrup.
The composition of the tablet form of "Lomilan":
- loratadine 10 mg;
- corn starch;
- stearic acid;
- lactobiosis;
- gelatinized starch.
Lomilan flat tablets have a rounded shape, are not painted, have a white color and a dividing risk in the center. 10 pieces are sealed in a blister. The drug is placed in a cardboard box of 1, 2 or 3 blisters. Also on sale is a mini-format of Lomilan tablets - 7 pieces in one cellular package.
The composition of the suspension "Lomilan":
- loratadine - 1 mg;
- purified water;
- CITRIC ACID;
- dipropylene glycol;
- twin 80;
- Avicel RC 591;
- benzoic acid sodium salt;
- cherry flavoring;
- sodium citric acid;
- sugar crystals;
- concentrated glycerol.
The suspension is a suspension of white particles. The drug is placed in a 120 ml glass darkened vial.The kit includes 1 bottle and 1 measuring spoon, placed in a cardboard box with instructions for use.
Pharmacological action, pharmacodynamics and pharmacokinetics
The basis of "Lomilan" contains the active substance loratadine. It has a systemic effect on histamine receptors.
The drug relieves itching, eliminates allergic reactions, blocks the secretion of fluid in inflamed tissues, thereby reducing swelling, and blocks spasmodic smooth muscle syndrome.
The conducted studies did not reveal any effect of the drug on the central nervous system; it is not addictive.
The therapeutic effect of taking the medication begins 30 minutes after oral administration and is stable throughout the day. The peak activity of loratadine is observed 8 to 12 hours after ingestion.
Once in the digestive tract, the substance is completely absorbed and penetrates into the plasma. On average, it takes 1 hour to completely absorb into the blood.
When “Lomilan” is used, metabolic processes occur in the liver cells, accompanied by the formation of the substance descarboethoxyloratadine. Withdrawal of the drug from the body begins after a decrease in peak activity, i.e., after 8 hours. With liver pathologies, in old age or with chronic alcoholism, the elimination half-life is prolonged. The breakdown products of the drug are excreted through urine and bile.
Why Lomilan is prescribed for children and adults
Allergy medication is prescribed for both adults and small patients.
The range of indications for use includes:
- inflammation of the conjunctival membrane of an allergic nature;
- seasonal or chronic allergic rhinitis;
- atypical reactions to insect bites;
- allergic reactions to the skin;
- false allergy.
Instructions for use of tablets and syrup
The drug is intended for oral administration. Lomilan tablets are prescribed for adults in a dosage of 10 mg per day. After ingestion, the drug must be washed down with plenty of water. The tablets can be chewed and taken with food.
Tablets dosage standards for tablets:
- 10 mg per day for adults and children over 3 years old;
- 5 mg per day for children under 3 years of age or weighing less than 29 kg.
Dosage standards for the use of suspension:
- 10 ml per day for patients older than 2 years;
- 5 ml per day for children over 2 years of age, whose weight is less than 29 kg.
In pediatrics, as a rule, Lomilan syrup for children is used, prepared on the basis of a suspension.
There are special instructions for the use of the drug for patients suffering from liver dysfunction. In this case, the dosage is halved and taken 1 tablet (or 2 scoops) every other day. A similar regimen is prescribed for people with kidney failure. For children from 3 to 6 years of age having the indicated pathology, 1 measured spoon of suspension (or half a tablet) is prescribed after 24 hours.
In the presence of mild and moderate forms of kidney disease, dose adjustment of the drug is not required. For older people, the drug is also prescribed in a standard amount.
The duration of taking "Lomilan" depends on the severity of symptoms. In the absence of positive dynamics within 72 hours, the possibility of replacing the medication with a more effective drug should be discussed with the attending physician.
Parallel reception of “Lomilan” and taking skin samples for allergens is undesirable, because the results of the studies will be distorted, and it will be impossible to identify a reliable picture. Therefore, 48 hours before the analysis, the use of the drug must be stopped.
Subject to the standard dosage, Lomilan does not affect the speed of mental and motor reactions. However, if atypical reactions to the drug occur or if the standard dosage is exceeded, it is better to temporarily avoid those types of activity that involve a risk (for example, driving a vehicle).
During pregnancy and lactation
Studies of the degree of passability of loratadine through the placental barrier and effects on the fetus have not been conducted. Considering that among the contraindications for taking the drug, children under 2 years old are noted, the use of Lomilan during the period of bearing a child is strictly contraindicated.
After taking the active substance, the drug passes into breast milk. Therefore, during lactation, such therapy is also contraindicated. If there is an urgent need for it, then feeding will have to be stopped and the child transferred to artificial mixtures.
Drug interaction
There are certain subtleties in the interaction of Lomilan with other drugs. In particular, there are substances that can increase the level of active components in plasma proteins, or vice versa, almost negate the effect of taking loratadine.
The former include cimetidine and ketoconazole. The second group includes inducers of xenobiotic transformation reactions (tricyclic antidepressants, rifampicin, methylcarbinol, diphenin, sedatives of the barbiturate group).
Contraindications, side effects and overdose
The use of "Lomilan" is strictly prohibited under such conditions and conditions:
- early childhood up to 2 years for syrup and up to 3 years for tablets;
- an allergy to one of the components of the drug;
- hypolactasia;
- lactase deficiency;
- the period of bearing and feeding the child;
- fructosemia;
- glucose-galactose malabsorption syndrome;
- sucrose-isomaltase deficiency.
In some cases, therapy using Lomilan is indicated, but under constant medical monitoring of the patient's condition.
Among them:
- violation of the liver;
- renal failure, in which less than 30 ml of blood is filtered per minute.
Taking the drug may be accompanied by side effects. So, in children, drowsiness, headaches or excessive irritability are sometimes noted.
In adult patients, a negative reaction to the drug can be expressed as:
- xerostomia;
- sedation;
- nausea
- migraine;
- asthenia;
- gastritis;
- malfunctioning of the liver;
- allergies, manifested by a rash on the skin;
- pathological hair loss;
- anaphylaxis.
If the “Lomilan” intake norm prescribed by a specialist is exceeded, an overdose is possible, accompanied by migraine, increased fatigue, and a rapid heartbeat.
To eliminate such symptoms, the drug should be removed from the body and slow down its absorption. This will help gastric lavage and the intake of activated charcoal.
Analogs of Lomilan
The drug has several twins that are similar in principle to the action.
Among them:
- Loridine
- "Loratadin Teva";
- Claridol
- Loratadine
- LORAHEXAL;
- Clarisens
- Clarotadine
- "Erolin";
- "Loratadin-Akrikhin."
Despite the identical algorithm of exposure to the body, medicines vary significantly in price. It is mainly determined by the producing country (as a rule, European analogues are more expensive).
The possibility of replacing Lomilan with an analogue can only be considered by the attending physician, based on the results of the patient’s tests, and not on the basis of the popularity or cost of the drug.
