Treatment measures for diseases of the gastrointestinal tract are necessarily carried out using the De-Nol gastroprotector, a medication that protects the gastric mucosa, envelops and promotes its recovery. However, for effective treatment, you should know how to drink De-Nol and what contraindications exist for it.
Material Content:
The composition of the drug
The main active component of this drug is bismuth salts - one tablet contains 304.6 mg (which is equal to 120 mg) of tripotassium bismuth dicitrate. Among the additional compounds of the active composition of magnesium are stearate, starch, potassium polyacrylate, hypromellose, povidone, as well as some others that are contained in small quantities.
pharmachologic effect
De-Nol tablets act as a complex drug that affects the entire gastrointestinal tract. A fairly broad list of its actions includes gastroprotection (protection of the gastric mucosa), as well as astringent, anti-inflammatory, antiseptic and antibacterial effects. Pharmacological properties are due to the regenerative abilities of preparations containing bismuth. In the acidic environment of the stomach, the medication forms a protective layer on the surface of erosion, which further contributes to scarring of lesions and protection of the mucosa from aggressive external factors.
And also a feature of De Nol is that it is able to exert an antimicrobial effect against pathogenic microorganisms, in particular helicobacter. Based on this, De-Nol is often prescribed for gastritis and other pathologies that cause peptic ulcer disease or dyskinesia. And just as importantly, even with prolonged use, bacteria are not able to develop resistance to the drug. Due to its gastroprotective properties, gastric juice in combination with enzymes does not harm damaged areas. And also during therapy, there is a decrease in pepsin activity, a decrease in the production of hydrochloric acid and a protective effect, which positively affects the gastric mucosa.
What is de-nol prescribed
This drug can be prescribed for various disorders, pathologies and many diseases.
The De-Nol medication is highly effective in cases with such digestive disorders:
- An ulcer or other deep lesion of the digestive tract (acute or chronic course). There is a relief of pain and the elimination of other manifestations of the disease.
- Gastroduodenitis, gastritis of any form and other diseases associated with the defeat of pathogenic microorganisms.
- Frequent bouts of heartburn.
- Irritable bowel syndrome.
- With the negative effects of non-steroidal anti-inflammatory drugs.
- Functional dyspepsia.
A timely started course of therapeutic treatment with De-Nol will relieve unpleasant consequences and pain.
Method of application, dosage for children and adults
To start therapy with this medication, an appointment from a specialist is necessary, since self-treatment can be hazardous to health. The duration of therapy, the course of treatment and dosage directly depend on the patient's age, severity and nature of the disorder.
Reception is carried out in several ways:
- adults and children over 14 years old - 2 tablets half an hour before meals (morning and evening);
- patients younger than 14 years old - on an empty stomach half an hour before meals, 1 tablet 3 times a day, and then - 1 tablet at bedtime;
Tablets must be swallowed intact - divided into parts, chewed, or crushed is not allowed. You should also drink the medicine with a sufficient amount of liquid, excluding milk, juices and nectars. Any such liquids impair the absorption of the drug. The duration of treatment is from one to two months. At the end of therapy, the patient should, for at least one month, not take drugs containing bismuth due to its cumulative abilities.
A medicinal medication is necessarily used separately from food intake, as well as any other drugs, since this affects its absorption and subsequent exposure. It’s also crucial to remember that milk drinks, fruit and vegetable juices significantly affect the absorption and properties of De-Nol.
Use during pregnancy and lactation
According to the instructions in the instructions for use, De-Nol is strictly prohibited for use by pregnant women, as well as during breastfeeding. This indication is due to the ability of the active compound to penetrate deep into the tissue, passing through the placental barrier and affecting the fetus. As well as bismuth salts have the ability to penetrate into breast milk, therefore, during therapeutic treatment should stop lactation.
Interaction with other drugs
During therapy with an anti-ulcer drug, any other drugs that contain bismuth are completely excluded: for example, such as Vikair, Bisal or Vicalin. If this indication is not followed, the patient is likely to have negative consequences, which include encephalopathy and renal failure.And it is also important to note the fact that the drug can reduce the absorption of antibiotic drugs. And the simultaneous use of De-Nol with drugs for the treatment of acid-dependent diseases lowers the pharmacological properties of the former.
Contraindications, side effects, overdose
The patient should definitely read the instructions for use, since De-Nol, like any other medication, has a number of contraindications.
It is strictly not recommended to take a therapeutic agent in such conditions:
- impaired kidney function;
- inadequate response of the immune system (hypersensitivity, allergic reaction) to some components in the composition;
- pregnancy and lactation;
- taking other drugs that contain bismuth;
- children under 14 years old.
You can not take De-Nol in childhood, but in some cases, therapy with this drug is justified. In case of emergency, children from 4 years of age are assigned an individual treatment regimen. The specialist needs to independently choose the daily dosage and duration of therapy. As a rule, a therapeutic agent acts as an addition to antibiotic drugs.
But also the possibility of the occurrence of adverse reactions from the body is not excluded.
During therapy, patients may experience the following side effects:
- Attacks of nausea, vomiting, indigestion and stool, lack of appetite.
- Deterioration of health, apathy, weakness.
- Metallic taste in the mouth.
- Changing the color of the surface of the tongue, feces.
- Individual manifestations in the form of an allergic reaction, urticaria.
It is extremely dangerous to take the drug in high doses for a long period of time, since De No has accumulative properties. Otherwise, the development of nephropathy, encephalopathy, arthralgia, colitis and some other lesions of the central nervous system is not ruled out. The remaining adverse reactions often disappear after a few days and do not require discontinuation of the drug.
If the prescribed dosage is not observed, an overdose often occurs. As a result, the patient feels signs of severe intoxication, as well as problems with the kidneys. In this case, symptomatic treatment, gastric lavage, laxatives and sorbents are taken. A critical excess of the normal dosage causes acute poisoning and, as a result, impaired filtration capacity of the kidneys (insufficiency). In extremely difficult situations, hemodialysis (extrarenal blood purification) is necessary.
Analogs of De Nola
The synonyms that can replace De-Nol include the following analogues: Omeprazole, Gastal, Nolpaza, Omez, Ranitidine. The listed therapeutic agents are almost completely consistent in terms of component composition, pharmacological properties and contraindications. Before self-replacing the prescribed drug, you must consult a specialist.
