Duspatalin, an active antispasmodic drug with high therapeutic efficacy, relieves spasmodic attacks of pain in the digestive organs due to the relaxation of muscle fibers in the tissues of the intestines, stomach, elimination of painful abnormal contractions and expansion of the bile and pancreatic ducts. The medication belongs to the group of myotropic antispasmodics, but does not affect the physiological motor activity of the intestine, which allows you to weaken the strength of the spasm without slowing the speed of transportation of the food lump.

Release forms and composition

Duspatalin is produced in two therapeutic formats: in the form of round white tablets in the shell, soluble in the gastrointestinal tract, or in white oblong capsules with an extended therapeutic effect.

The medicinal basis of both forms is mebeverin.

The tablet contains 135 mg of the therapeutic component, in capsules the amount of mebeverin is increased to 200 mg.

The composition of the medication also includes inactive components, which are represented by excipients and preservatives.

Packing of medicinal forms of duspatalin provides for their placement in plastic-aluminum blisters of 10, 15, 20 units. In the pharmacy pack can be from 1 to 6 blisters. In addition, capsules can be purchased in PVC jars with packaging of 30 and 60 pieces.

Pharmacological action, pharmacodynamics and pharmacokinetics

The therapeutic component in the drug acts directly on the smooth muscle tissues of the digestive system.

As a result of the activity of mebeverin occurs:

  • the weakening or complete elimination of pain caused by spasm by relaxing muscle fibers in the tissues of the intestine, stomach, bile duct and pancreatic ducts;
  • local expansion of small and large vessels, which improves blood supply to all organ structures, impaired by spasmodic contractions;
  • restored nutrition and normal functioning of organs.

Mebeverin selectively relaxes the sphincter of Oddi - the muscle ring that regulates the evacuation of bile and pancreatic juice into the intestine, and does not allow its contents to be thrown back into the ducts of the gallbladder and pancreas. Experts emphasize that in terms of their ability to relax the sphincter, Duspatalin is about 30 times more active than Papaverine.

The advantage of Duspatalin as an antispasmodic is the absence of influence:

  • on the cholinergic system, so that during treatment there are no such unpleasant phenomena as constipation, dry mouth, weakness, visual disturbances, heart palpitations, poor sleep, urinary retention.
  • on the natural motor function of the intestine, due to which no unpleasant consequences such as gas accumulation, bloating, constipation occur during therapy.

The absorption of the active substance occurs quickly, but its significant accumulation in plasma and tissues is not observed. The time of pronounced manifestation of the therapeutic effect is 3 hours after administration.

Mebeverin undergoes a complete enzymatic treatment in the liver, where it is broken down to metabolites (intermediate substances) - veratra and demethylated carboxylic acids and mebeverin alcohol, which are excreted together with urine. The period of removal from the body of half the formed carboxylic acid is about 6 hours.

Why is Duspatalin prescribed?

Duspatalin helps with various inflammatory and functional diseases of the pancreas, digestive organs, gall bladder, including gastritis, pancreatitis, cholecystitis, ulcerative lesions of the stomach and intestines, when there are cramps and pain caused by irritation of nerve receptors in the compressed muscle fibers and stretching of the ducts of patients.

Indications for Duspatalin are pain symptoms against the background of abdominal cramps caused by the following types of abnormal conditions:

  1. Spastic pain caused by organic diseases such as cholecystitis, cholangitis, pancreatitis. Biliary colic or an acute attack of pancreatitis is accompanied by spasm and narrowing of the lumen of the excretory ducts. After removing the spasm, the lumen of the ducts expands, which leads to the elimination of stagnation of bile, pancreatic juice and their free outflow.
  2. Intestinal colic.
  3. Biliary dyskinesia (a disorder of the motility of the gallbladder and its ducts).
  4. Disorders of the function of the stomach and intestines, including colitis, gastritis, peptic ulcer, accompanied by spastic pain.
  5. Irritable bowel syndrome.
  6. Pylorospasm is an abnormally painful contraction of the pylorus (muscle sphincter in the lower segment of the stomach).
  7. The recovery period after surgery to remove the gallbladder.

The action of Duspatalin is aimed specifically at the relaxation of smooth muscle cells of the digestive secretory organs, so many gastroenterologists believe that in the treatment of diseases associated with the digestive system, Duspatalin shows a more pronounced result and fewer adverse reactions than Papaverine and drugs based on drotaverine (No-spa )

Instructions for use and dosage

Application Features:

  1. Duspatalin 135 mg tablets, like capsules, are taken before meals in about 20 minutes, washed down with liquid in the volume necessary for the patient.
  2. The duration of the course is associated with the type of disease and the severity of symptoms. You can take the medicine once, and it will quickly relieve painful manifestations in uncomplicated disorders of the digestive organs. If the patient experiences spastic pains against the background of long-term pathologies, therapy can last up to 15 to 20 days or longer as directed by the doctor.
  3. With prolonged use of the drug, it is not allowed to cancel the intake immediately, so as not to cause undesirable reactions characteristic of the “withdrawal syndrome”.

135 mg tablets

The treatment regimen using this therapeutic form of the drug provides for a three-time intake of 1 tablet at approximately equal time intervals.

Capsules 200 mg

This dosage form of the drug is prescribed only to adults from 18 years of age. Due to the fact that the dosage form Duspatalin 200 mg Prolong has an extended therapeutic effect due to the gradual release of mebeverine, this allows you to take capsules 2 times a day after about 10 to 12 hours.

Pediatric use

In the instructions for the use of mebeverin, the basic treatment substance in Duspatalin, there are various recommendations for the use of antispasmodics for children.

Based on these data, we can conclude:

  1. Until the age of 12, the medicine is forbidden to use at all.
  2. Duspatalin capsules with a dosage of 200 mg are not advisable to give to patients aged 16 to 18 years, since accurate data on the effect of such an amount of the substance on the body at this age is not enough.
  3. For teenagers from the age of 12, many pediatricians prescribe pills (due to the lesser amount of mebeverin in them) to suppress pain attacks in functional disorders of the stomach, pancreas, intestines, biliary dyskinesia, pancreatitis. In this case, a two-time use of 1 tablet is prescribed.

The main thing that parents need to know is not to treat the teenager on their own, but to consult a gastroenterologist for recommendations.

During pregnancy and lactation

Information on the effects of mebeverin on the body of nursing mothers, infants receiving breast milk, pregnant patients, the development of the embryo and the course of pregnancy is not enough, since full studies have not been conducted. In this regard, doctors do not prescribe Duspatalin during these periods.

The medicine is allowed to be used only in case of clinical events that threaten the life of pregnant women, if there are no other proven and safer medications. In this case, it is recommended that nursing mothers transfer the infant to infant formula.

Duspatalin Compatibility with Alcohol

Ethanol intake during therapy increases the incidence of side effects, or enhances those that are already manifested.

Drug interaction

The biochemical effect of mebeverin on other pharmacological substances, as well as the reverse effect, was not detected.

Contraindications, side effects and overdose

Among the main contraindications:

  • intolerance to mebeverin or any component of the medication;
  • age up to 12 (for all treatment forms) and up to 18 years (for capsules) - due to the high content of the active component and the lack of data on the effectiveness and safety of the drug for this age group;
  • pregnancy (due to lack of information);
  • breastfeeding (no data).

Use with caution in therapy:

  • patients with severe hepatic-renal failure, cardiac pathologies;
  • patients with gastroesophageal reflux - due to the relaxing effect on the lower sphincter of the esophagus, which contributes to the throwing of gastric contents into the esophagus and provoking heartburn and irritation of the mucosa.

Side unpleasant effects when taking a medication are very rare:

  • nausea, discomfort in the stomach;
  • skin rash, itching;
  • constipation or loose stools.

Reducing the frequency of administration helps to eliminate these phenomena.

In isolated cases, there are:

  • vomiting, urticaria;
  • swelling of the lips, eyelids, tongue, larynx (with acute anaphylaxis);
  • dizziness.

Such conditions require immediate withdrawal of the medicine, and in case of severe manifestations of allergies (edema, shortness of breath, pain behind the sternum, tachycardia) - an immediate call to the ambulance.

In case of an overdose, existing side effects occur, or intensify. Overexcitation, vomiting, and jumps in blood pressure occur.

To weaken the action of mebeverin, you can rinse the stomach (within an hour after taking the last dose), take absorbent medications (preferably Polysorb), and remedies to eliminate symptoms that are painful for the patient.

Analogs

Duspatalin's analogs in composition or synonyms are Sparex, Mebeverin, Niaspam, Meverin.

Other myotropic antispasmodics with similar therapeutic effect - Dietetel, Spazgan, Buskopan, No-shpa, Drotaverin, Spazmalgon, Trigan, Papaverine, Trimedat.

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