Bisoprolol is one of the most popular drugs in the treatment of hypertension. The drug comprehensively affects the functioning of the cardiovascular system and quickly reduces high blood pressure, however, it has a large number of side effects. Poor tolerance imposes a number of restrictions on the administration of tablets, which must be familiarized with before starting therapy. You should not take this medication without a doctor’s prescription.

Release form, composition and packaging

The active substance in Bisoprolol tablets is the drug of the same name. In pharmacies, three dosages are presented - 2.5, 5 and 10 mg of the active ingredient in one tablet of an antihypertensive drug. The tablets are small in size, round, painted in a light pink color. The composition contains lactose, cellulose, silicon dioxide and other formative components, dyes.

The medicine is produced by various pharmaceutical companies, so the type of packaging may vary. As a rule, a cardboard pack of white color with a pink stripe or inscription. Tablets are placed in contour cells of 10 pieces, in the package - 1, 2 or 3 blisters. Also, in pharmacies, Bisoprolol is found in 30 or 60 tablets in a polymer jar, packed in a cardboard box.

The drug is prescription. Before purchasing, you need to consult your doctor about the required dosage for ease of use, otherwise you will have to break the tablet, which does not always allow you to correctly calculate the dose of the medicine.

Pharmacological action and pharmacokinetics

Selective beta1-blocker has a pronounced hypotensive and anti-ischemic effect, which determines the scope of its application.

Properties of the drug:

  • decrease in heart rate during exercise and at rest;
  • decrease in cardiac output;
  • decreased vascular tone;
  • decreased contractile function of the myocardium;
  • decrease in myocardial oxygen demand;
  • decreased plasma renin activity.

Thus, Bisoprolol tablets have a complex effect on the cardiovascular system, improving the quality of life of patients with hypertension, coronary heart disease and angina pectoris.

The effect of the drug begins 3 hours after taking a therapeutic dose. The half-life is about 12 hours, in general, the action of the pill taken is enough for almost a full day. This greatly facilitates the treatment of hypertension, as it exempts from taking a large number of medications during the day.

To obtain the maximum antihypertensive effect, it is necessary to take tablets at the prescribed dosage for two weeks. It is important to take daily at the same time.

The absorption of the drug does not depend on the meal time, the bioavailability of the drug is almost 90%. Withdrawal of the drug from the body is carried out simultaneously by the kidneys and liver.

Why is the drug prescribed?

Bisoprolol is prescribed for hypertension to lower blood pressure. It is recommended to take it with systolic blood pressure above 135 mm Hg. Art. The advisability of taking bisoprolol tablets at very high pressure is determined by the doctor. As a rule, with hypertension of the 3rd degree, combination therapy is recommended, Bisoprolol as an independent remedy is ineffective.

Note! The antihypertensive effect begins at least 3 hours after administration, which makes the drug ineffective in case of hypertensive crisis.

Another indication for the appointment is coronary heart disease, also called angina pectoris. As part of combination therapy, the drug can be used for chronic heart failure.

Indications for use are given in the official instructions, however, the advisability of taking the drug depends, first of all, on the severity of hypertension in the patient. The medication should be agreed with the attending physician; self-medication with bisoprolol can be hazardous to health.

Instructions for use and dosage regimen

The official instructions for use contain clear instructions for taking the drug, but the dosage regimen can be changed by the doctor.

The tablet should be taken in the morning before breakfast, preferably at the same time. It should be swallowed whole without chewing and drinking plenty of plain water.

Treatment begins with the minimum therapeutic dose, continues for two weeks, and then assesses the effectiveness of therapy. With insufficient antihypertensive effect, an increase in the dosage of the drug is allowed.

In coronary artery disease, the initial therapeutic dose is 5 mg per day. The same amount of medication is prescribed for grade 2 hypertension, however, with a slight increase in blood pressure, you can carry out therapy with tablets in a dosage of 2.5 mg.

With stable chronic failure, small doses of the drug are practiced with a weekly increase in the number of tablets.So, in the first week, ½ tablets of 2.5 mg are prescribed, the second week the treatment is carried out by taking one tablet at this dosage, 1.25 mg of the drug is added after another week. The duration of maintenance therapy in a dosage of more than 5 mg is determined individually for each patient.

Tablets 2.5 mg, 5 mg and 10 mg

For ease of administration, the drug is presented in several dosages. Many patients prefer to choose a medicine in a larger dosage, and then divide the tablet into several parts for administration. This is due to a slight difference in the cost of the drug 2.5 and 10 mg. At the same time, Bisoprolol has a cumulative effect, so it is important to ensure the regular intake of the same dose of the drug in the body. It is difficult to do this when breaking the tablet, the probability of error is high. Thus, doctors recommend that the medicine be purchased at the dosage that the patient needs for treatment.

During pregnancy and lactation

Drugs in this group negatively affect the course of pregnancy.

Taking Bisoprolol during childbearing can lead to insufficiency of placental blood flow, which is fraught with impaired fetal development or premature birth.

It is not known whether the active substance can pass into breast milk and affect the baby. In this regard, it is recommended to abandon the use of drugs for hypertension during pregnancy and lactation, preferring antihypertensive drugs that are safe for pregnant women. In this case, the attending physician will help you choose the best medicine.

Drug interaction

The drug should not be taken with calcium antagonists and central antihypertensive drugs. Such combinations lead to a deterioration in atrioventricular conduction, can cause bradycardia and worsen the course of heart failure.

With hypertension, it is forbidden to take bisoprolol-based drugs in conjunction with class I antiarrhythmic drugs.

The antihypertensive effect can be significantly weakened while taking with non-steroidal anti-inflammatory drugs. In such cases, there is a high risk of a decrease in the effect of the treatment of hypertension.

Patients with diabetes mellitus should be especially careful, since insulin and sugar-lowering drugs can lose part of the therapeutic effect when taking the medicine for hypertension.

The patient should notify the doctor if he takes other medications in conjunction with bisoprolol. This will allow you to adjust the regimen of drugs and avoid negative drug interactions.

Bisoprolol Compatibility with Alcohol

At the time of treatment, you should completely abandon alcohol intake. An antihypertensive drug can enhance the effect of ethanol on the nervous system. In addition, this combination increases the load on the liver and slows down the excretion of Bisoprolol metabolites.

Special instructions for admission

Bisoprolol refers to medicines intended for long-term use. You can not abruptly stop taking pills from pressure, as this can lead to the development of rebound hypertension. Drug withdrawal is carried out by gradually reducing the dosage.

Diabetic patients should carefully monitor the fluctuation in blood sugar, as a medicine for hypertension can mask the symptoms of hypoglycemia.

The medicine can lead to impaired sexual function in men. In this case, you need to visit a doctor and consult about the possibility of replacing the drug with a drug with another active substance.

Contraindications, side effects and overdose

The drug should not be taken if:

  • intolerance to the active substance;
  • lactose intolerance;
  • bradycardia;
  • acute or decompensated heart failure;
  • COPD
  • metabolic acidosis.

Before prescribing the drug, it is necessary to undergo a comprehensive examination.A history of cardiogenic shock and recent myocardial infarction are a contraindication to taking Bisoprolol tablets.

Side effects:

  • vertigo, cephalalgia;
  • nightmares;
  • bradycardia;
  • dyspeptic disorders;
  • depressive disorder.

If dangerous psyche symptoms appear (depressive thoughts, anxiety, apathy), consult a doctor. Such symptoms are a strong argument in favor of drug withdrawal.

An overdose manifests itself in acute heart failure with bradycardia and impaired lung function. There is no specific antidote, the patient needs urgent resuscitation measures with subsequent support of the cardiovascular system.

Analogs

To choose analogues of Bisoprolol is not difficult.

Preparations with the same composition:

  • Hypertension;
  • Concor;
  • Arithel.

If the need to replace the medicine is due to the occurrence of side effects, you should ask your doctor to choose an analogue based on another active substance.

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